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Reduced Somatostatin Expression or Somatostatin-Positive Gamma-Aminobutyric Acid Neurons: A Shared Pathology Across Brain Disorders

  • Etienne Sibille
    Correspondence
    Address correspondence to Etienne Sibille, Ph.D., Centre for Addiction and Mental Health, 250 College Street, Room 134, Toronto, OntarioM5T 1R8, Canada; .
    Affiliations
    Campbell Family Mental Health Research Institute of Centre for Addiction and Mental Health

    Departments of Psychiatry and of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
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      The clinical and biological heterogeneity that pervades the field of neuropsychiatry has hindered progress in uncovering the pathophysiological mechanisms of psychiatric illnesses. Indeed, it is rare to come across well-replicated pathological findings within or across disorders, and when such findings do arise they merit our attention and focus. In this issue, Pantazopoulos et al. (
      • Pantazopoulos H.
      • Wiseman J.T.
      • Markota M.
      • Ehrenfeld L.
      • Berretta S.
      Decreased numbers of somatostatin-expressing neurons in the amygdala of subjects with bipolar disorder or schizophrenia: Relationship to circadian rhythms.
      ) bring forward a pathological feature that is common to postmortem brains of patients with schizophrenia and bipolar disorder and that is shared by other psychiatric or neurodegenerative brain disorders (
      • Lin L.C.
      • Sibille E.
      Reduced brain somatostatin in mood disorders: A common pathophysiological substrate and drug target?.
      ).
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