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Circuit-Based Corticostriatal Homologies Between Rat and Primate

      ABSTRACT

      Background

      Understanding the neural mechanisms of psychiatric disorders requires the use of rodent models; however, frontal-striatal homologies between rodents and primates are unclear. In contrast, within the striatum, the shell of the nucleus accumbens, the hippocampal projection zone, and the amygdala projection zone (referred to as the striatal emotion processing network [EPN]) are conserved across species. We used the relationship between the EPN and projections from the anterior cingulate cortex (ACC) and orbitofrontal cortex (OFC) to assess network similarities across rats and monkeys.

      Methods

      We first compared the location and extent of each major component of the EPN in rats and macaques. Next, we used anatomic cases with anterograde injections in ACC/OFC to determine the extent to which corticostriatal terminal fields overlapped with these components and with each other.

      Results

      The location and size of each component of the EPN were similar across species, containing projections primarily from infralimbic cortex in rats and area 25 in monkeys. Other ACC/OFC terminals overlapped extensively with infralimbic cortex/area 25 projections, supporting cross-species similarities in OFC topography. However, dorsal ACC had different connectivity profiles across species. These results were used to segment the monkey and rat striata according to ACC/OFC inputs.

      Conclusions

      Based on connectivity with the EPN, and consistent with prior literature, the infralimbic cortex and area 25 are likely homologues. We also see evidence of OFC homologies. Along with segmenting the striatum and identifying striatal hubs of overlapping inputs, these results help to translate findings between rodent models and human pathology.

      Keywords

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      Linked Article

      • Making the Right Connections
        Biological PsychiatryVol. 80Issue 7
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          Recent years have seen the application of increasingly powerful transgenic, optogenetic, and chemogenetic methodologies in rodents. Armed with these tools, many studies have shown how perturbations of specific subregions of the rodent frontal cortex can elicit circumscribed behavioral phenotypes that resemble key aspects of psychiatric disorders. For example, the rodent frontal cortex can be broadly divided into motor, medial prefrontal cortex (mPFC), and orbitofrontal cortex (OFC) divisions; the mPFC can be further subdivided into prelimbic (PL), infralimbic (IL), and cingulate (Cg) cortices, while the OFC comprises the medial orbital (MO) and ventral and lateral orbital (VOLO) cortices.
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