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Address correspondence to John H. Krystal, M.D., Department of Psychiatry, Yale University School of Medicine, 300 George Street, Suite 901, New Haven, CT 06511;
Department of Psychiatry and Neuroscience, Yale University School of Medicine, New Haven, ConnecticutBehavioral Health Services, Yale New Haven Hospital, New Haven, ConnecticutClinical Neuroscience Division, VA Connecticut Healthcare System, West Haven, ConnecticutDepartments of Psychiatry and Radiology, Columbia University, New York, New York
Department of Psychiatry and Neuroscience, Yale University School of Medicine, New Haven, ConnecticutChild Study Center, Yale University School of Medicine, New Haven, Connecticut
Departments of Psychiatry and Psychology and the Brain Research Institute, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, California
Department of Psychiatry and Behavioral and Neuroscience Institute, University of Cambridge, Cambridge, United KingdomImmunoPsychiatry, GlaxoSmithKline, Cambridge, United Kingdom
Department of Psychiatry and Behavioral Sciences, Imaging Research Center, and Center for Neuroscience, University of California at Davis, Davis, California
Temerty Centre for Therapeutic Brain Intervention, Mood and Anxiety Division Centre for Addiction and Mental Health, Toronto, Ontario, CanadaDepartment of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Genetic Neuropathology Section, Lieber Institute for Brain Development, and Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
Human Brain Collection Core, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
Semel Institute for Neuroscience, University of California at Los Angeles, Los Angeles, CaliforniaVA Desert Pacific Mental Illness Research, Education, and Clinical Center, Los Angeles, California
Department of Psychiatry, University of California at San Francisco, San Francisco, CaliforniaPsychiatry Service, San Francisco VA Medical Center, San Francisco, California
Massachusetts General Hospital and MassGeneral Hospital for Children, Lurie Center for Autism, Lexington, MassachusettsDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts
Human Genetics Branch and Genetic Basis of Mood and Anxiety Disorders Section, National Institute of Mental Health, Intramural Research Program, Bethesda, Maryland
Departments of Psychology and Neuroscience, Institute of Psychiatry, King’s College London, London, United KingdomPsychiatry and Immunology Lab & Perinatal Psychiatry, The Maurice Wohl Clinical Neuroscience Institute, London, United Kingdom
Neuropsychiatric disorders constitute the single greatest source of the global burden
of disease, but it seems that philanthropy and advocacy aimed at supporting research
to alleviate the burden of these disorders often are overshadowed by corresponding
efforts in many other areas of medicine. For example, the United States public donates
five times more money to cancer than to mental health research (
). In this context, it is particularly sobering that we recently lost two towering
mental health advocates and philanthropists, Constance E. Lieber and Theodore R. Stanley
(Figures 1 and 2). These two individuals made an enormous and enduring impact through the initiatives
that they created and sustained, through their personal contributions, and through
their ability to mobilize others. For the editors, editorial board members, and editorial
committee members of Biological Psychiatry who constitute the authors of this commentary, the losses are personal. Each of us
has received research support made possible through the actions of these unique individuals.
In acknowledging our gratitude, we hope that our collective efforts to advance the
understanding of mental illness and its treatment are a lasting testament to their
impact.
