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Mood Disorder Psychopharmacology Unit, University Health Network, Department of Psychiatry, Department of Pharmacology, and Institute of Medical Science, University of Toronto, Toronto, Canada
Sleep disruption and/or alterations in sleep cycle or quality are identified within
the Research Domain Criteria (RDoC) matrix as a transdiagnostic phenomenology (
). In addition, sleep disturbances are highly associated with adverse psychiatric
and physical health outcomes. Results from epidemiologic and clinical samples, as
well as experimental sleep manipulation studies, provide convergent evidence that
alterations in sleep are associated with reproducible abnormalities across multiple
effector systems relevant to the pathophysiology of psychiatric and medical disorders
(
). Observations of biological perturbation associated with sleep may inform a broader
conceptual framework (i.e., RDoC) as it regards disease modeling in psychiatric and
medical disorders. For example, sleep disturbance, and its associated neurobiological
alterations, may be relevant to the vulnerability, direct causality, illness propagation,
comorbidity, and treatment of psychiatric disorders (Figure 1).
Figure 1Disturbances in sleep are a critical component of the shared pathogenetic nexus between
psychiatric and cardiometabolic disorders.
Sleep disturbance is associated with inflammatory disease risk and all-cause mortality. Here, we assess global evidence linking sleep disturbance, sleep duration, and inflammation in adult humans.
