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Intrinsic Local Beta Oscillations in the Subgenual Cingulate Relate to Depressive Symptoms in Treatment-Resistant Depression

      The subgenual anterior cingulate cortex (sgACC) is central to emotional processing circuits and exhibits hyperactivity in treatment-resistant depression (TRD) (
      • Mayberg H.S.
      • Liotti M.
      • Brannan S.K.
      • McGinnis S.
      • Mahurin R.K.
      • Jerabek P.A.
      • et al.
      Reciprocal limbic-cortical function and negative mood: Converging PET findings in depression and normal sadness.
      ), making it a promising target in deep brain stimulation (DBS) treatment (
      • Mayberg H.S.
      • Lozano A.M.
      • Voon V.
      • McNeely H.E.
      • Seminowicz D.
      • Hamani C.
      • et al.
      Deep brain stimulation for treatment-resistant depression.
      ). Neural oscillations reflect rhythmic activity from voltage fluctuations over time, which may be responsible for the aberrant sgACC activity seen in brain imaging studies. Oscillations at different frequencies have been linked with a broad range of cognitive, emotional, and sensorimotor processing.
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