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Moving Toward Understanding the Proteome Involved in Substance Abuse

  • Sean P. Farris
    Correspondence
    Address correspondence to Sean P. Farris, Ph.D., Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, 2500 Speedway, A4800, Austin, TX 78712.
    Affiliations
    Waggoner Center for Alcohol and Addiction Research and Center for Computational Biology and Bioinformatics, The University of Texas at Austin, Austin, Texas
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      Addiction to alcohol and other drugs of abuse is a persistent mental health disorder adversely affecting the individuals with the disorder as well as society at large. Initial substance use and subsequent chronic abuse affect multiple brain systems and biological pathways. The transition to a substance use disorder entails interacting molecular components within the central nervous system (CNS), forming a dense network of proteins capable of being usurped by abused substances. Deciphering the affected components throughout the life cycle of addiction is essential for understanding the neurobiological complexity of this mental health disorder and for rational design of pharmacotherapies.
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