Tourette syndrome (TS) is a childhood-onset neuropsychiatric disorder that affects neural circuits involved in sensory and motor processing as well as cognitive control. Tics consist of repetitive, unwanted, non–goal-directed muscle contractions involving discrete muscle groups, which are associated with preceding sensory phenomena (urges) and are variably suppressible by volition (
1). Most individuals with TS experience improvement of their tics in late adolescence or early adulthood. However, a few individuals have severe and self-injurious tics that are refractory to currently available behavioral and pharmacologic interventions. Untreated, severe tics can lead to permanent disability and injury (e.g., severe head snapping tics leading to permanent injury to the cervical spinal cord or persistent eye-poking tics leading to blindness).
Martino D. Leckman J.F. Tourette Syndrome. Oxford University Press, New York2013
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- Martino D. Leckman J.F. Tourette Syndrome. Oxford University Press, New York2013
- Tourette syndrome deep brain stimulation: A review and updated recommendations.Mov Disord. 2015; 30: 448-471
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Accepted: November 25, 2015
Received: November 18, 2015
© 2016 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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- Motor Improvement and Emotional Stabilization in Patients With Tourette Syndrome After Deep Brain Stimulation of the Ventral Anterior and Ventrolateral Motor Part of the ThalamusBiological PsychiatryVol. 79Issue 5
- PreviewSince its first application in 1999, the potential benefit of deep brain stimulation (DBS) in reducing symptoms of otherwise treatment-refractory Tourette syndrome (TS) has been documented in several publications. However, uncertainty regarding the ideal neural targets remains, and the eventuality of so far undocumented but possible negative long-term effects on personality fuels the debate about the ethical implications of DBS.