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Ventral and Dorsal Striatum Networks in Obesity: Link to Food Craving and Weight Gain

  • Oren Contreras-Rodríguez
    Affiliations
    Red de Trastornos Adictivos, Universidad de Granada, Granada

    Psychiatry Department, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, and Centro de Investigación Biomédica en Red de Salud Mental, Barcelona
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  • Cristina Martín-Pérez
    Affiliations
    Red de Trastornos Adictivos, Universidad de Granada, Granada

    Institute of Neuroscience F. Oloriz, Universidad de Granada, Granada, Spain
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  • Raquel Vilar-López
    Affiliations
    Red de Trastornos Adictivos, Universidad de Granada, Granada

    Mind, Brain and Behavior Research Center, Universidad de Granada, Granada, Spain
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  • Antonio Verdejo-Garcia
    Correspondence
    Address correspondence to: Antonio Verdejo-García, Ph.D., Monash University, School of Psychological Sciences, 18 Innovation Walk (Clayton Campus), Melbourne 3800, Australia.
    Affiliations
    Red de Trastornos Adictivos, Universidad de Granada, Granada

    Institute of Neuroscience F. Oloriz, Universidad de Granada, Granada, Spain

    School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Melbourne, Australia
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Published:December 03, 2015DOI:https://doi.org/10.1016/j.biopsych.2015.11.020

      Abstract

      Background

      The food addiction model proposes that obesity overlaps with addiction in terms of neurobiological alterations in the striatum and related clinical manifestations (i.e., craving and persistence of unhealthy habits). Therefore, we aimed to examine the functional connectivity of the striatum in excess-weight versus normal-weight subjects and to determine the extent of the association between striatum connectivity and individual differences in food craving and changes in body mass index (BMI).

      Methods

      Forty-two excess-weight participants (BMI > 25) and 39 normal-weight participants enrolled in the study. Functional connectivity in the ventral and dorsal striatum was indicated by seed-based analyses on resting-state data. Food craving was indicated with subjective ratings of visual cues of high-calorie food. Changes in BMI between baseline and 12 weeks follow-up were assessed in 28 excess-weight participants. Measures of connectivity in the ventral striatum and dorsal striatum were compared between groups and correlated with craving and BMI change.

      Results

      Participants with excess weight displayed increased functional connectivity between the ventral striatum and the medial prefrontal and parietal cortices and between the dorsal striatum and the somatosensory cortex. Dorsal striatum connectivity correlated with food craving and predicted BMI gains.

      Conclusions

      Obesity is linked to alterations in the functional connectivity of dorsal striatal networks relevant to food craving and weight gain. These neural alterations are associated with habit learning and thus compatible with the food addiction model of obesity.

      Keywords

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