The correspondence from Jeffries and Perkins (
1
) raises an important potential limitation of data repositories. Our original publication
(
2
) used tissue from the Stanley Medical Research Institute (SMRI) Array Collection
(Chevy Chase, Maryland). According to the terms of use of this tissue, samples were
provided for analysis blind to diagnosis and other clinical and laboratory variables.
Raw data were returned to the SMRI before the code linking samples to the descriptive
data was provided. The data analyzed in the correspondence from Jeffries and Perkins
appear to be these raw data, presumably obtained directly from the SMRI database (individual
subject data were not included as supplemental data in our 2011 publication, and we
have not provided it to anyone other than the SMRI).To read this article in full you will need to make a payment
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References
- Reproducibility and visual inspection of data.Biol Psychiatry. 2016; 80: e33-e35
- Altered microRNA expression profiles in postmortem brain samples from individuals with schizophrenia and bipolar disorder.Biol Psychiatry. 2011; 69: 188-193
Article info
Publication history
Published online: November 25, 2015
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© 2016 Society of Biological Psychiatry.
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Access this article on ScienceDirectLinked Article
- Reproducibility and Visual Inspection of DataBiological PsychiatryVol. 80Issue 5
- PreviewIn 2011, Moreau et al. (1) reported in Biological Psychiatry findings concerning patterns of microRNA (miRNA) expression in postmortem samples from prefrontal cortex (Brodmann area 9) from the Stanley Medical Research Institute (SMRI) (Chevy Chase, Maryland). They used advanced statistical techniques and miRNA assays by real-time quantitative polymerase chain reaction (2) (TaqMan probes; Applied Biosystems, Foster City, California) for the canonical sequences in early versions of miRBase ( http://www.mirbase.org/ ) (3).
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