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Reply to: Reproducibility and Visual Inspection of Data

Published:November 25, 2015DOI:https://doi.org/10.1016/j.biopsych.2015.11.011
      The correspondence from Jeffries and Perkins (
      • Jeffries C.D.
      • Perkins D.O.
      Reproducibility and visual inspection of data.
      ) raises an important potential limitation of data repositories. Our original publication (
      • Moreau M.P.
      • Bruse S.E.
      • David-Rus R.
      • Buyske S.
      • Brzustowicz L.M.
      Altered microRNA expression profiles in postmortem brain samples from individuals with schizophrenia and bipolar disorder.
      ) used tissue from the Stanley Medical Research Institute (SMRI) Array Collection (Chevy Chase, Maryland). According to the terms of use of this tissue, samples were provided for analysis blind to diagnosis and other clinical and laboratory variables. Raw data were returned to the SMRI before the code linking samples to the descriptive data was provided. The data analyzed in the correspondence from Jeffries and Perkins appear to be these raw data, presumably obtained directly from the SMRI database (individual subject data were not included as supplemental data in our 2011 publication, and we have not provided it to anyone other than the SMRI).
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      References

        • Jeffries C.D.
        • Perkins D.O.
        Reproducibility and visual inspection of data.
        Biol Psychiatry. 2016; 80: e33-e35
        • Moreau M.P.
        • Bruse S.E.
        • David-Rus R.
        • Buyske S.
        • Brzustowicz L.M.
        Altered microRNA expression profiles in postmortem brain samples from individuals with schizophrenia and bipolar disorder.
        Biol Psychiatry. 2011; 69: 188-193

      Linked Article

      • Reproducibility and Visual Inspection of Data
        Biological PsychiatryVol. 80Issue 5
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          In 2011, Moreau et al. (1) reported in Biological Psychiatry findings concerning patterns of microRNA (miRNA) expression in postmortem samples from prefrontal cortex (Brodmann area 9) from the Stanley Medical Research Institute (SMRI) (Chevy Chase, Maryland). They used advanced statistical techniques and miRNA assays by real-time quantitative polymerase chain reaction (2) (TaqMan probes; Applied Biosystems, Foster City, California) for the canonical sequences in early versions of miRBase ( http://www.mirbase.org/ ) (3).
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