Advertisement

FKBP5 Messenger RNA Increases After Adolescence in Human Dorsolateral Prefrontal Cortex

Published:November 17, 2015DOI:https://doi.org/10.1016/j.biopsych.2015.11.005
      Stress before or during adolescence can increase the risk of transitioning to psychotic illness (
      • Bechdolf A.
      • Thompson A.
      • Nelson B.
      • Cotton S.
      • Simmons M.B.
      • Amminger G.P.
      • et al.
      Experience of trauma and conversion to psychosis in an ultra-high-risk (prodromal) group.
      ,
      • Velthorst E.
      • Nelson B.
      • O’Connor K.
      • Mossaheb N.
      • de Haan L.
      • Bruxner A.
      • et al.
      History of trauma and the association with baseline symptoms in an ultra-high risk for psychosis cohort.
      ,
      • Yung A.R.
      • Yuen H.P.
      • McGorry P.D.
      • Phillips L.J.
      • Kelly D.
      • Dell’Olio M.
      • et al.
      Mapping the onset of psychosis: The Comprehensive Assessment of At-Risk Mental States.
      ,
      • Tessner K.D.
      • Mittal V.
      • Walker E.F.
      Longitudinal study of stressful life events and daily stressors among adolescents at high risk for psychotic disorders.
      ,
      • Miller P.
      • Lawrie S.M.
      • Hodges A.
      • Clafferty R.
      • Cosway R.
      • Johnstone E.C.
      Genetic liability, illicit drug use, life stress and psychotic symptoms: Preliminary findings from the Edinburgh study of people at high risk for schizophrenia.
      ). Furthermore, stress during the chronic phases of major mental illness can exacerbate symptoms (
      • Day R.
      • Nielsen J.A.
      • Korten A.
      • Ernberg G.
      • Dube K.C.
      • Gebhart J.
      • et al.
      Stressful life events preceding the acute onset of schizophrenia: A cross-national study from the World Health Organization.
      ,
      • Nugent K.L.
      • Chiappelli J.
      • Rowland L.M.
      • Hong L.E.
      Cumulative stress pathophysiology in schizophrenia as indexed by allostatic load.
      ,
      • Ventura J.
      • Nuechterlein K.H.
      • Subotnik K.L.
      • Hardesty J.P.
      • Mintz J.
      Life events can trigger depressive exacerbation in the early course of schizophrenia.
      ). Understanding how stress affects the brain at different ages may provide insight into the molecular mechanisms that lead to human brain dysfunction.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Bechdolf A.
        • Thompson A.
        • Nelson B.
        • Cotton S.
        • Simmons M.B.
        • Amminger G.P.
        • et al.
        Experience of trauma and conversion to psychosis in an ultra-high-risk (prodromal) group.
        Acta Psychiatr Scand. 2010; 121: 377-384
        • Velthorst E.
        • Nelson B.
        • O’Connor K.
        • Mossaheb N.
        • de Haan L.
        • Bruxner A.
        • et al.
        History of trauma and the association with baseline symptoms in an ultra-high risk for psychosis cohort.
        Psychiatry Res. 2013; 210: 75-81
        • Yung A.R.
        • Yuen H.P.
        • McGorry P.D.
        • Phillips L.J.
        • Kelly D.
        • Dell’Olio M.
        • et al.
        Mapping the onset of psychosis: The Comprehensive Assessment of At-Risk Mental States.
        Aust N Z J Psychiatry. 2005; 39: 964-971
        • Tessner K.D.
        • Mittal V.
        • Walker E.F.
        Longitudinal study of stressful life events and daily stressors among adolescents at high risk for psychotic disorders.
        Schizophr Bull. 2011; 37: 432-441
        • Miller P.
        • Lawrie S.M.
        • Hodges A.
        • Clafferty R.
        • Cosway R.
        • Johnstone E.C.
        Genetic liability, illicit drug use, life stress and psychotic symptoms: Preliminary findings from the Edinburgh study of people at high risk for schizophrenia.
        Soc Psychiatry Psychiatr Epidemiol. 2001; 36: 338-342
        • Day R.
        • Nielsen J.A.
        • Korten A.
        • Ernberg G.
        • Dube K.C.
        • Gebhart J.
        • et al.
        Stressful life events preceding the acute onset of schizophrenia: A cross-national study from the World Health Organization.
        Cult Med Psychiatry. 1987; 11: 123-205
        • Nugent K.L.
        • Chiappelli J.
        • Rowland L.M.
        • Hong L.E.
        Cumulative stress pathophysiology in schizophrenia as indexed by allostatic load.
        Psychoneuroendocrinology. 2015; 60: 120-129
        • Ventura J.
        • Nuechterlein K.H.
        • Subotnik K.L.
        • Hardesty J.P.
        • Mintz J.
        Life events can trigger depressive exacerbation in the early course of schizophrenia.
        J Abnorm Psychol. 2000; 109: 139-144
        • Diorio D.
        • Viau V.
        • Meaney M.J.
        The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress.
        J Neurosci. 1993; 13: 3839-3847
        • Mizoguchi K.
        • Ishige A.
        • Aburada M.
        • Tabira T.
        Chronic stress attenuates glucocorticoid negative feedback: Involvement of the prefrontal cortex and hippocampus.
        Neuroscience. 2003; 119: 887-897
        • Wochnik G.M.
        • Ruegg J.
        • Abel G.A.
        • Schmidt U.
        • Holsboer F.
        • Rein T.
        FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells.
        J Biol Chem. 2005; 280: 4609-4616
        • Binder E.B.
        • Bradley R.G.
        • Liu W.
        • Epstein M.P.
        • Deveau T.C.
        • Mercer K.B.
        • et al.
        Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults.
        JAMA. 2008; 299: 1291-1305
        • Binder E.B.
        • Salyakina D.
        • Lichtner P.
        • Wochnik G.M.
        • Ising M.
        • Putz B.
        • et al.
        Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment.
        Nat Genet. 2004; 36: 1319-1325
        • Klengel T.
        • Mehta D.
        • Anacker C.
        • Rex-Haffner M.
        • Pruessner J.C.
        • Pariante C.M.
        • et al.
        Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions.
        Nat Neurosci. 2013; 16: 33-41
        • Sinclair D.
        • Fillman S.G.
        • Webster M.J.
        • Weickert C.S.
        Dysregulation of glucocorticoid receptor co-factors FKBP5, BAG1 and PTGES3 in prefrontal cortex in psychotic illness.
        Sci Rep. 2013; 3: 3539
        • Sinclair D.
        • Fullerton J.M.
        • Webster M.J.
        • Shannon Weickert C.
        Glucocorticoid receptor 1B and 1C mRNA transcript alterations in schizophrenia and bipolar disorder, and their possible regulation by GR gene variants.
        PLoS One. 2012; 7: e31720
        • Sinclair D.
        • Tsai S.Y.
        • Woon H.G.
        • Shannon Weickert C.
        Abnormal glucocorticoid receptor mRNA and protein isoform expression in the prefrontal cortex in psychiatric illness.
        Neuropsychopharmacology. 2011; 36: 2698-2709
        • Sinclair D.
        • Webster M.J.
        • Fullerton J.M.
        • Weickert C.S.
        Glucocorticoid receptor mRNA and protein isoform alterations in the orbitofrontal cortex in schizophrenia and bipolar disorder.
        BMC Psychiatry. 2012; 12: 84
        • Webster M.J.
        • Knable M.B.
        • O’Grady J.
        • Orthmann J.
        • Weickert C.S.
        Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders.
        Mol Psychiatry. 2002; 7: 985-994
        • Kilidireas K.
        • Latov N.
        • Strauss D.H.
        • Gorig A.D.
        • Hashim G.A.
        • Gorman J.M.
        • et al.
        Antibodies to the human 60 kDa heat-shock protein in patients with schizophrenia.
        Lancet. 1992; 340: 569-572
        • Kim J.J.
        • Lee S.J.
        • Toh K.Y.
        • Lee C.U.
        • Lee C.
        • Paik I.H.
        Identification of antibodies to heat shock proteins 90 kDa and 70 kDa in patients with schizophrenia.
        Schizophr Res. 2001; 52: 127-135
        • Kim J.J.
        • Mandelli L.
        • Lim S.
        • Lim H.K.
        • Kwon O.J.
        • Pae C.U.
        • et al.
        Association analysis of heat shock protein 70 gene polymorphisms in schizophrenia.
        Eur Arch Psychiatry Clin Neurosci. 2008; 258: 239-244
        • Willour V.L.
        • Chen H.
        • Toolan J.
        • Belmonte P.
        • Cutler D.J.
        • Goes F.S.
        • et al.
        Family-based association of FKBP5 in bipolar disorder.
        Mol Psychiatry. 2009; 14: 261-268
        • Kakiuchi C.
        • Ishiwata M.
        • Nanko S.
        • Kunugi H.
        • Minabe Y.
        • Nakamura K.
        • et al.
        Association analysis of HSP90B1 with bipolar disorder.
        J Hum Genet. 2007; 52: 794-803
        • Arion D.
        • Unger T.
        • Lewis D.A.
        • Levitt P.
        • Mirnics K.
        Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia.
        Biol Psychiatry. 2007; 62: 711-721
        • Sinclair D.
        • Webster M.J.
        • Wong J.
        • Weickert C.S.
        Dynamic molecular and anatomical changes in the glucocorticoid receptor in human cortical development.
        Mol Psychiatry. 2011; 16: 504-515
        • Weickert C.S.
        • Elashoff M.
        • Richards A.B.
        • Sinclair D.
        • Bahn S.
        • Paabo S.
        • et al.
        Transcriptome analysis of male-female differences in prefrontal cortical development.
        Mol Psychiatry. 2009; 14: 558-561
        • Bick J.
        • Nelson C.A.
        Early adverse experiences and the developing brain.
        Neuropsychopharmacology. 2016; 41: 177-196
        • Lupien S.J.
        • McEwen B.S.
        • Gunnar M.R.
        • Heim C.
        Effects of stress throughout the lifespan on the brain, behaviour and cognition.
        Nat Rev Neurosci. 2009; 10: 434-445