It has become clear over the past 30 years that there is no discrete “lesion” underlying the symptoms of schizophrenia and related disorders. Rather, many investigators have come to view schizophrenia as fundamentally a disorder of dysconnection within and between certain functional networks in the brain (
1). At this broad level of description, understanding the symptoms of psychosis as emanating from dyscoordination in multiple, interacting circuits has intuitive appeal that links key concepts and findings in the field from the time of Bleuler, with its focus on associative loosening as a basic symptom, to the current day, with its focus on functional neuroimaging, graph analytic approaches, and mechanisms of synaptic plasticity. However, consensus is lacking on which networks are critically affected and what pattern or level of dysconnection within and between them is sufficient for expression of psychotic symptoms. In other words, at the present time, the field lacks a theoretical framework that makes strong predictions about whether people with or at risk for psychosis should show higher or lower levels of functional or structural connectivity within or between any given set of brain regions (
- Stephan K.E.
- Friston K.J.
- Frith C.D.
Dysconnection in schizophrenia: From abnormal synaptic plasticity to failures of self-monitoring.
Schizophr Bull. 2009; 35: 509-527
- Cannon T.D.
What is the role of theories in the study of schizophrenia?.
Schizophr Bull. 2009; 35: 563-567
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Biological Psychiatry
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Dysconnection in schizophrenia: From abnormal synaptic plasticity to failures of self-monitoring.Schizophr Bull. 2009; 35: 509-527
- What is the role of theories in the study of schizophrenia?.Schizophr Bull. 2009; 35: 563-567
- Dendritic spine pathology in schizophrenia.Neuroscience. 2013; 251: 90-107
- Discrete alternations of brain network structural covariance in individuals at ultra-high risk for psychosis.Biol Psychiatry. 2015; 77: 989-996
- A review of structural neuroimaging in schizophrenia: From connectivity to connectomics.Front Hum Neurosci. 2014; 8: 653
- Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.Nature. 2009; 460: 748-752
- Early and late neurodevelopmental influences in the prodrome to schizophrenia: Contributions of genes, environment, and their interactions.Schizophr Bull. 29. 2003: 653-669
- Stress and the hypothalamic pituitary adrenal axis in the developmental course of schizophrenia.Annu Rev Clin Psychol. 2008; 4: 189-216
- Progressive reduction in cortical thickness as psychosis develops: A multisite longitudinal neuroimaging study of youth at elevated clinical risk.Biol Psychiatry. 2015; 77: 147-157
- Variable global dysconnectivity and individual differences in schizophrenia.Biol Psychiatry. 2011; 70: 43-50
Accepted: March 18, 2015
Received: March 17, 2015
© 2015 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
ScienceDirectAccess this article on ScienceDirect
- Discrete Alterations of Brain Network Structural Covariance in Individuals at Ultra-High Risk for PsychosisBiological PsychiatryVol. 77Issue 11
- PreviewInvestigation of aberrant large-scale brain networks offers novel insight into the role these networks play in diverse psychiatric disorders such as schizophrenia. Although studies report altered functional brain connectivity in participants at ultra-high risk (UHR) for psychosis, it is unclear whether these alterations extend to structural brain networks.