The study by Warnica et al. (
1
) investigates a clever and straightforward idea. Of course, there is substantial
evidence to support the role of rare genomic copy number variants (CNVs) in schizophrenia
and other neuropsychiatric disease (
2
). A role for specific microRNA pathways (miRNAs) in schizophrenia has also been convincingly
demonstrated in a variety of ways (
3
,
4
). For example, the well-known schizophrenia-associated deletion at 22q11.2 includes
both miR-185 as well as the gene DGCR8, a component of the microprocessor complex
that is involved in the initial step of miRNA biogenesis. Warnica et al. (
1
) have now conducted a genome-wide test to determine if rare CNVs are enriched for
miRNA loci. Their results demonstrate that this is indeed the case, and they further
attempt to map the putative targets of these miRNAs in an effort to uncover molecular
mechanisms in the disorder.To read this article in full you will need to make a payment
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References
- Copy number variable microRNAs in schizophrenia and their neurodevelopmental gene targets.Biol Psychiatry. 2015; 77: 158-166
- Genomic copy number variation in disorders of cognitive development.J Am Acad Child Adolesc Psychiatry. 2010; 49: 1091-1104
- Genome-wide association study identifies five new schizophrenia loci.Nat Genet. 2011; 43: 969-976
Xu B, Hsu PK, Karayiorgou M, Gogos J (2012): MicroRNA dysregulation in neuropsychiatric disorders and cognitive dysfunction. Neurobiol Dis 46:291–301.
- 22q11 deletion syndrome in adults with schizophrenia.Am J Med Genet. 1998; 81: 328-337
- Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11.Proc Natl Acad Sci U S A. 1995; 92: 7612-7616
- Increased expression of activity-dependent genes in cerebellar glutamatergic neurons of patients with schizophrenia.Am J Psychiatry. 2006; 163: 1829-1831
- Activity-dependent transcription and disorders of human cognition.Am J Psychiatry. 2009; 166: 14-15
- Rare chromosomal deletions and duplications increase risk of schizophrenia.Nature. 2008; 455: 237-241
- Biological insights from 108 schizophrenia-associated genetic loci.Nature. 2014; 511: 421-427
Article info
Publication history
Accepted:
November 7,
2014
Received:
November 7,
2014
Identification
Copyright
© 2015 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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- Copy Number Variable MicroRNAs in Schizophrenia and Their Neurodevelopmental Gene TargetsBiological PsychiatryVol. 77Issue 2
- PreviewMicroRNAs (miRNAs) are key regulators of gene expression in the human genome and may contribute to risk for neuropsychiatric disorders. miRNAs play an acknowledged role in the strongest of genetic risk factors for schizophrenia, 22q11.2 deletions. We hypothesized that in schizophrenia there would be an enrichment of other rare copy number variants (CNVs) that overlap miRNAs.
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