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Leveraging Genetics and Genomics to Define the Causes of Mental Illness

  • Matthew W. State
    Affiliations
    Department of Psychiatry and Langley Porter Psychiatric Institute, University of California, San Francisco, San Francisco.
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  • Daniel H. Geschwind
    Correspondence
    Address correspondence to Daniel H. Geschwind, M.D., Ph.D., UCLA Center for Autism Research and Treatment, 2506 Gonda, 695 Charles E. Young Drive South, Los Angeles, CA 90095-1761.
    Affiliations
    UCLA Center for Autism Research and Treatment, University of California, Los Angeles, Los Angeles, California.
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      Psychiatric genetics is in the midst of a profound transformation. For decades, the primary challenge for the field was simply the reliable identification of risk genes. Now, for multiple disorders, the path to systematic discovery is clear. Recent findings in studies of schizophrenia, autism, bipolar disorder, and substance abuse have demonstrated that a comprehensive elucidation of genetic risk factors is now within reach—dependent only on sufficient sample sizes and the resources to pursue these studies. The findings so far have already laid the groundwork to begin the next epoch in unraveling the complexity of brain-based behavioral and emotional syndromes: from the illumination of pathophysiologic mechanisms, to a clarification of the relative contribution of genetics and environment, to a reappraisal and likely revision of the categorical psychiatric diagnostic nosology based on etiology.
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      References

        • Gelernter J.
        Genetics of complex traits in psychiatry.
        Biol Psychiatry. 2015; 77: 36-42
        • Lehner T.
        • Senthil G.
        • Addington A.M.
        Convergence of advances in genomics, team science, and repositories as drivers of progress in psychiatric genomics.
        Biol Psychiatry. 2015; 77: 6-14
        • Hall J.
        • Trent S.
        • Thomas K.L.
        • O’Donovan M.C.
        • Owen M.J.
        Genetic risk for schizophrenia: Convergence on synaptic pathways involved in plasticity.
        Biol Psychiatry. 2015; 77: 52-58
        • Horváth S.
        • Mirnics K.
        Schizophrenia as a disorder of molecular pathways.
        Biol Psychiatry. 2015; 77: 22-28
        • Karch C.M.
        • Goate A.M.
        Alzheimer’s disease risk genes and mechanisms of disease pathogenesis.
        Biol Psychiatry. 2015; 77: 43-51
        • Glahn D.C.
        • Williams J.T.
        • McKay D.R.
        • Knowles E.E.
        • Sprooten E.
        • Mathias S.R.
        • et al.
        Discovering schizophrenia endophenotypes in randomly ascertained pedigrees.
        Biol Psychiatry. 2015; 77: 75-83
        • Donaldson Z.R.
        • Hen R.
        From psychiatric disorders to animal models: A bidirectional and dimensional approach.
        Biol Psychiatry. 2015; 77: 15-21
        • Kim Y.S.
        • Leventhal B.
        Genetic epidemiology and insights into interactive genetic and environmental effects in neurodevelopmental disorders.
        Biol Psychiatry. 2015; 77: 66-74
        • Hamilton S.P.
        The promise of psychiatric pharmacogenomics.
        Biol Psychiatry. 2015; 77: 29-35
        • Kohane I.S.
        An autism case history to review the systematic analysis of large-scale data to refine the diagnosis and treatment of neuropsychiatric disorders.
        Biol Psychiatry. 2015; 77: 59-65