The extent to which schizophrenia (SZ) and psychotic bipolar disorder (BD) represent
distinct illnesses has been the focus of debate since Kraepelin and Blueler’s early
descriptions of dementia praecox and manic depressive insanity. Their hope, expressed
more than a century ago, was that the tools of neuroscience at the time (“clinical
observation, the microscope and experimentation”) would lead to improved understanding
and treatments of these devastating disorders. In the past century, spectacular advances
have occurred at the intersections of neuroscience, psychopharmacology, and genomics.
However, few, if any, laboratory tests to inform diagnoses, guide treatments, and
monitor response to interventions have graduated from laboratories to clinics. Clinicians
still must rely on behavioral observation and careful interview techniques to make
inferences about patients’ inner experiences and deductions about the impacted neural
systems. Although we have refined indirect clinical assessments for diagnosis and
treatment, these methods have evolved relatively little since the late 19th century.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Biological PsychiatryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Psychiatry: A Textbook for Students and Physicians. Vol 1. Science History Publications, Canton, OH1899
- Event-related potential and time-frequency endophenotypes for schizophrenia and psychotic bipolar disorder.Biol Psychiatry. 2015; 77: 127-136
- Dynamic brain sources of visual evoked responses.Science. 2002; 295: 690-694
- Investigation of relationships between fMRI brain networks in the spectral domain using ICA and Granger causality reveals distinct differences between schizophrenia patients and healthy controls.Neuroimage. 2009; 46: 419-431
- Electroencephalography correlates of spatial working memory deficits in attention-deficit/hyperactivity disorder: Vigilance, encoding, and maintenance.J Neurosci. 2014; 34: 1171-1182
- Using biomarkers to inform diagnosis, guide treatments and track response to interventions in psychotic illnesses.Biomark Med. 2014; 8: 9-14
- Cortical substrates and functional correlates of auditory deviance processing deficits in schizophrenia.Neuroimage Clin. 2014; 6: 424-437
- Neurophysiological biomarkers informing the clinical neuroscience of schizophrenia: Mismatch negativity and prepulse inhibition of startle.Curr Top Behav Neurosci. 2014; 21: 293-314
- In search of biomarkers in psychiatry: EEG-based measures of brain function.Am J Med Genet B Neuropsychiatr Genet. 2014; 165B: 111-121
- Using neuroplasticity-based auditory training to improve verbal memory in schizophrenia.Am J Psychiatry. 2009; 166: 805-811
Light GA, Swerdlow NR, Thomas ML, Calkins ME, Green MF, Greenwood TA, et al. (in press): Validation of mismatch negativity and P3a for use in multi-site studies of schizophrenia: Characterization of demographic, clinical, cognitive, and functional correlates in COGS-2. Schizophr Res. http://dx.doi.org/10.1016/j.schres.2014.09.042.
Article info
Publication history
Accepted:
November 5,
2014
Received:
November 3,
2014
Identification
Copyright
Published by Elsevier Inc.
ScienceDirect
Access this article on ScienceDirectLinked Article
- Event-Related Potential and Time-Frequency Endophenotypes for Schizophrenia and Psychotic Bipolar DisorderBiological PsychiatryVol. 77Issue 2
- PreviewThe investigators compared event-related potential (ERP) amplitudes and event-related oscillations across a broad frequency range during an auditory oddball task using a comprehensive analysis approach to describe shared and unique neural auditory processing characteristics among healthy subjects (HP), schizophrenia probands (SZ) and their first-degree relatives, and bipolar disorder I with psychosis probands (BDP) and their first-degree relatives.
- Full-Text
- Preview
