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Investigation of the Prenatal Expression Patterns of 108 Schizophrenia-Associated Genetic Loci

  • Rebecca Birnbaum
    Affiliations
    Lieber Institute for Brain Development, Johns Hopkins University School of Medicine, Baltimore, Maryland

    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland
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  • Andrew E. Jaffe
    Affiliations
    Lieber Institute for Brain Development, Johns Hopkins University School of Medicine, Baltimore, Maryland
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  • Qiang Chen
    Affiliations
    Lieber Institute for Brain Development, Johns Hopkins University School of Medicine, Baltimore, Maryland
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  • Thomas M. Hyde
    Affiliations
    Lieber Institute for Brain Development, Johns Hopkins University School of Medicine, Baltimore, Maryland

    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland

    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland
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  • Joel E. Kleinman
    Affiliations
    Lieber Institute for Brain Development, Johns Hopkins University School of Medicine, Baltimore, Maryland
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  • Daniel R. Weinberger
    Correspondence
    Address correspondence to Daniel R. Weinberger, M.D., Lieber Institute for Brain Development, Johns Hopkins University School of Medicine, 855 North Wolfe Street, Baltimore, MD 21205
    Affiliations
    Lieber Institute for Brain Development, Johns Hopkins University School of Medicine, Baltimore, Maryland

    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland

    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland

    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland

    Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
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      We recently reported the results of an investigation of the prenatal expression patterns of genes associated with neuropsychiatric disorders by analysis of a microarray-based dorsolateral prefrontal cortex transcriptome (
      • Birnbaum R.
      • Jaffe A.E.
      • Hyde T.M.
      • Kleinman J.E.
      • Weinberger D.R.
      Prenatal expression patterns of genes associated with neuropsychiatric disorder.
      ). We found that genes associated with autism, intellectual disability, and syndromic neurodevelopmental disorders revealed a pattern of relative prenatal enrichment, whereas genes associated with schizophrenia by genome-wide association were not prenatally enriched in transcript abundance, at least not as a composite gene set. We now write to update our analysis, incorporating the recently published schizophrenia-associated loci from the Psychiatric Genomics Consortium (
      Schizophrenia Working Group of the Psychiatric Genomics Consortium
      Biological insights from 108 schizophrenia-associated genetic loci.
      ).
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