We recently reported the results of an investigation of the prenatal expression patterns
of genes associated with neuropsychiatric disorders by analysis of a microarray-based
dorsolateral prefrontal cortex transcriptome (
1
). We found that genes associated with autism, intellectual disability, and syndromic
neurodevelopmental disorders revealed a pattern of relative prenatal enrichment, whereas
genes associated with schizophrenia by genome-wide association were not prenatally
enriched in transcript abundance, at least not as a composite gene set. We now write
to update our analysis, incorporating the recently published schizophrenia-associated
loci from the Psychiatric Genomics Consortium (
2
).To read this article in full you will need to make a payment
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References
- Prenatal expression patterns of genes associated with neuropsychiatric disorder.Am J Psychiatry. 2014; 171: 758-767
- Biological insights from 108 schizophrenia-associated genetic loci.Nature. 2014; 511: 421-427
- Temporal dynamics and genetic control of transcription in the human prefrontal cortex.Nature. 2011; 478: 519-523
- Gemma: A resource for the reuse, sharing and meta-analysis of expression profiling data.Bioinformatics. 2012; 28: 2272-2273
Carlson M. org.Hs.eg.db: Genome wide annotation for Human. R package version 2.14.0.
- Schizophrenia as a disorder of molecular pathways [published online ahead of print Jan 10].Biol Psychiatry. 2014;
- Infragranular gene expression disturbances in the prefrontal cortex in schizophrenia: Signature of altered neural development?.Neurobiol Dis. 2010; 37: 738-746
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Article Info
Publication History
Published online: October 21, 2014
Footnotes
☆The authors report no biomedical financial interests or potential conflicts of interest.
Identification
Copyright
© 2015 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
