Evaluation of neural systems and brain connections is an important new area of research
to understand both normal brain connectivity and alterations in brain connectivity
in neuropsychiatric disorders. The study of brain connectivity is also a major focus
of current neuroscience. In humans, very little is known about neural networks in
the living brain, although the Human Connectome Project (http://www.neuroscienceblueprint.nih.gov/connectome/) has as one of its main goals to understand better brain connections using the highest
quality imaging data available today. The focus on brain networks (or connectomes),
as opposed to single connections between brain regions, is a significant step forward
because neural networks can be studied using new sophisticated models that open up
avenues of research that make possible comprehensive analysis of structural and functional
brain connectivity in normal individuals and in individuals with neuropsychiatric
disorders, including attention-deficit/hyperactivity disorder (ADHD) (
1
,
2
). A connectomic approach to studying brain networks is also important because this
approach includes a deeper appreciation of the fact that even the smallest, seemingly
simplest task performed by humans engages multiple regions of the brain in organized
networks. Sporns (
) described several developmental and possible evolutionary factors that shape such
network topology.To read this article in full you will need to make a payment
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References
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Article info
Publication history
Accepted:
August 21,
2014
Received:
August 20,
2014
Identification
Copyright
Published by Elsevier Inc.
ScienceDirect
Access this article on ScienceDirectLinked Article
- Connectomic Disturbances in Attention-Deficit/Hyperactivity Disorder: A Whole-Brain Tractography AnalysisBiological PsychiatryVol. 76Issue 8
- PreviewFew studies have sought to identify, in a regionally unbiased way, the precise cortical and subcortical regions that are affected by white matter abnormalities in attention-deficit/hyperactivity disorder (ADHD). This study aimed to derive a comprehensive, whole-brain characterization of connectomic disturbances in ADHD.
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