Evaluation of neural systems and brain connections is an important new area of research to understand both normal brain connectivity and alterations in brain connectivity in neuropsychiatric disorders. The study of brain connectivity is also a major focus of current neuroscience. In humans, very little is known about neural networks in the living brain, although the Human Connectome Project (http://www.neuroscienceblueprint.nih.gov/connectome/) has as one of its main goals to understand better brain connections using the highest quality imaging data available today. The focus on brain networks (or connectomes), as opposed to single connections between brain regions, is a significant step forward because neural networks can be studied using new sophisticated models that open up avenues of research that make possible comprehensive analysis of structural and functional brain connectivity in normal individuals and in individuals with neuropsychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD) (
- Cao Q.
- Shu N.
- An L.
- Wang P.
- Sun L.
- Xia M.R.
- et al.
Probabilistic diffusion tractography and graph theory analysis reveal abnormal white matter structural connectivity networks in drug-naive boys with attention deficit/hyperactivity disorder.
J Neurosci. 2013; 33: 10676-10687
2). A connectomic approach to studying brain networks is also important because this approach includes a deeper appreciation of the fact that even the smallest, seemingly simplest task performed by humans engages multiple regions of the brain in organized networks. Sporns (
- Hong S.-B.
- Zalesky A.
- Fornito A.
- Park S.
- Yang Y.-H.
- Park M.-H.
- et al.
Connectomic disturbances in attention-deficit/hyperactivity disorder: A whole-brain tractography analysis.
Biol Psychiatry. 2014; 76: 656-663
3) described several developmental and possible evolutionary factors that shape such network topology.
- Sporns O.
Networks of the Brain.
The MIT Press, Cambridge, MA2010
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Biological Psychiatry
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Probabilistic diffusion tractography and graph theory analysis reveal abnormal white matter structural connectivity networks in drug-naive boys with attention deficit/hyperactivity disorder.J Neurosci. 2013; 33: 10676-10687
- Connectomic disturbances in attention-deficit/hyperactivity disorder: A whole-brain tractography analysis.Biol Psychiatry. 2014; 76: 656-663
- Networks of the Brain.The MIT Press, Cambridge, MA2010
- Trends in the parent-report of health care provider-diagnosed and medicated attention-deficit/hyperactivity disorder: United States, 2003-2011.J Am Acad Child Adolesc Psychiatry. 2014; 53: 34-46
- Brain differences between persistent and remitted attention deficit hyperactivity disorder.Brain. 2014; 137: 2423-2428
- Implication of right frontostriatal circuitry in response inhibition and attention-deficit/hyperactivity disorder.J Am Acad Child Adolesc Psychiatry. 1997; 36: 374-383
- Towards conceptualizing a neural systems-based anatomy of attention-deficit/hyperactivity disorder.Dev Neurosci. 2009; 31: 36-49
- Cortical development in typically developing children with symptoms of hyperactivity and impulsivity: Support for a dimensional view of attention deficit hyperactivity disorder.Am J Psychiatry. 2011; 168: 143-151
Accepted: August 21, 2014
Received: August 20, 2014
Published by Elsevier Inc.
ScienceDirectAccess this article on ScienceDirect
- Connectomic Disturbances in Attention-Deficit/Hyperactivity Disorder: A Whole-Brain Tractography AnalysisBiological PsychiatryVol. 76Issue 8
- PreviewFew studies have sought to identify, in a regionally unbiased way, the precise cortical and subcortical regions that are affected by white matter abnormalities in attention-deficit/hyperactivity disorder (ADHD). This study aimed to derive a comprehensive, whole-brain characterization of connectomic disturbances in ADHD.