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Reductions of p11 and 5-HT1B Receptor Availability in Limbic Brain Regions in Cocaine Dependence

  • Per Svenningsson
    Correspondence
    Address correspondence to Per Svenningsson, M.D., Ph.D., Karolinska Institutet, Department of Clinical Neuroscience, Center for Molecular Medicine, CMML8:01, Stockholm 171 76, Sweden
    Affiliations
    Center for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
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      Results from the 2012 National Survey on Drug Use and Health reported that approximately 1.6 million individuals aged 12 or over are cocaine abusers in the United States (
      Substance Abuse and Mental Health Services Administration
      Results from the 2012 National Survey on Drug Use and Health: Summary of National Findings.
      ). In addition, cocaine abusers often have comorbid disorders, and it has been estimated that 30% to 40% of individuals suffering from drug abuse have a mood or anxiety disorder (
      • Conway K.P.
      • Compton W.
      • Stinson F.S.
      • Grant B.F.
      Lifetime comorbidity of DSM-IV mood and anxiety disorders and specific drug use disorders: Results from the National Epidemiologic Survey on alcohol and related conditions.
      ). The high rate of comorbidity between mood disorders and cocaine dependence suggests shared anatomical pathways and molecular mechanisms. Accordingly, it has been reported that both depression and cocaine dependence are associated with alterations in the reward circuitry of the brain, particularly in the nucleus accumbens.
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      Linked Article

      • Cell-Type Specific Expression of p11 Controls Cocaine Reward
        Biological PsychiatryVol. 76Issue 10
        • Preview
          The high rate of comorbidity between depression and cocaine addiction suggests shared molecular mechanisms and anatomical pathways. Limbic structures, such as the nucleus accumbens (NAc), play a crucial role in both disorders, yet how different cell types within these structures contribute to the pathogenesis remains elusive. Downregulation of p11 (S100A10), specifically in the NAc, elicits depressive-like behaviors in mice, but its role in drug addiction is unknown.
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      • Reductions in Brain 5-HT1B Receptor Availability in Primarily Cocaine-Dependent Humans
        Biological PsychiatryVol. 76Issue 10
        • Preview
          Preclinical evidence implicates the serotonin receptor 5-hydroxytryptamine 1B (5-HT1B) in the effects of cocaine. This study explores 5-HT1B in humans by examining receptor availability in vivo in subjects whose primary addiction is cocaine dependence (CD) using positron emission tomography.
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