Over the past 5 years, the genome-wide association study (GWAS) method has produced
significant findings that are providing insights into the biological pathways involved
in disease susceptibility for both schizophrenia and bipolar disorder. Yet, we have
no such findings for major depressive disorder (MDD) (
1
)—the most common of these disorders, causing the greatest disability in the world
population. We were asked by the editor of this journal to comment on why progress
has been so difficult for MDD and how we can do better.To read this article in full you will need to make a payment
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References
- A mega-analysis of genome-wide association studies for major depressive disorder.Mol Psychiatry. 2013; 18: 497-511
- Biological insights from 108 schizophrenia-associated genetic loci.Nature. 2014; 511: 421-427
- Genome-wide association study identifies five new schizophrenia loci.Nat Genet. 2011; 43: 969-976
- The power of meta-analysis in genome-wide association studies.Annu Rev Genomics Hum Genet. 2013; 14: 441-465
- Common SNPs explain a large proportion of the heritability for human height.Nat Genet. 2010; 42: 565-569
- Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.Nat Genet. 2013; 45: 984-994
- Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.Nature. 2009; 460: 748-752
- Impact of diagnostic misclassification on estimation of genetic correlations using genome-wide genotypes.Eur J Hum Genet. 2012; 20: 668-674
- The impact of phenotypic and genetic heterogeneity on results of genome wide association studies of complex diseases.PloS One. 2013; 8: e76295
- The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women.Arch Gen Psychiatry. 2003; 60: 929-937
Article info
Publication history
Accepted:
July 14,
2014
Received:
July 11,
2014
Identification
Copyright
© 2014 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
