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Connectomics Reveals Faulty Wiring Patterns for Depressed Brain

  • Yanchao Bi
    Affiliations
    State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China
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  • Yong He
    Correspondence
    Address correspondence to Yong He, Ph.D., State Key Laboratory of Cognitive Neuroscience and Learning, and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China
    Affiliations
    State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China
    Search for articles by this author
      Uncovering the neural basis of psychiatric and neurological disorders is the foundation for the development of diagnosis and treatment programs. While disorder-related changes in focal brain areas and specific brain connections have been scrutinized, a recently developed research framework—human brain connectomics (
      • Sporns O.
      • Tononi G.
      • Kotter R.
      The human connectome: A structural description of the human brain.
      )—offers the opportunity to study the brain as a complex, integrative network. In a nutshell, a brain network can be constructed on the basis of connections (edges) among brain regions (nodes) derived from a variety of imaging data. The constructed networks can then be viewed as a graph, with mathematical measures available to quantify its various types of topological properties. Such methods reshape how brain structure and function can be conceptualized and studied and provide a whole new perspective of how diseased brain can be understood.
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