Multiple lines of evidence support a role for microRNA 137 (miR-137) in the etiology
of schizophrenia (
1
,
2
,
3
,
4
) and fundamental neuronal processes (
5
,
6
,
7
). In the largest genome-wide association meta-analysis for schizophrenia (
8
), the second most significant association is in MIR137HG, the gene encoding miR-137 (rs1702294; p = 3.4 × 10−19). Prior reports indicated that genes with predicted miR-137 target sites were enriched
for smaller genome-wide association studies p values (
2
), raising the possibility that miR-137 regulates a gene network involved in schizophrenia.
To understand more about the role of miR-137, we describe here our characterization
of embryonic development, behavior, and gene expression in mice with targeted disruption
of the Mir137 transcript (Supplement 1).To read this article in full you will need to make a payment
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References
- Genome-wide association study identifies five new schizophrenia loci.Nat Genet. 2011; 43: 969-976
- Genome-wide association analysis identifies 13 new risk loci for schizophrenia.Nat Genet. 2013; 45: 1150-1159
- Schizophrenia miR-137 locus risk genotype is associated with dorsolateral prefrontal cortex hyperactivation.Biol Psychiatry. 2014; 75: 398-405
- The genome-wide supported microRNA-137 variant predicts phenotypic heterogeneity within schizophrenia.Mol Psychiatry. 2013; 18: 443-450
- Cross talk between microRNA and epigenetic regulation in adult neurogenesis.J Cell Biol. 2010; 189: 127-141
- MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1.Stem Cells. 2010; 28: 1060-1070
- Chromosome 1p21.3 microdeletions comprising DPYD and MIR137 are associated with intellectual disability.J Med Genet. 2011; 48: 810-818
Schizophrenia Working Group of the Psychiatric Genomics Consortium (in press): Biological insights from 108 schizophrenia-associated genetic loci. Nature.
- A resource for the conditional ablation of microRNAs in the mouse.Cell Rep. 2012; 1: 385-391
- A reliable lacZ expression reporter cassette for multipurpose, knockout-first alleles.Genesis. 2004; 38: 151-158
Article info
Publication history
Published online: June 10, 2014
Footnotes
Authors JJC and ALC contributed equally to this work.
Identification
Copyright
© 2015 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
