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A Neurodevelopmental Perspective on the Research Domain Criteria (RDoC) Framework

      The National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) project is developing a research classification system for psychopathology based upon dimensions of neurobiology and observable behavior (
      • Insel T.
      • Cuthbert B.
      • Garvey M.
      • Heinssen R.
      • Pine D.S.
      • Quinn K.
      • et al.
      Research domain criteria (RDoc): Toward a new classification framework for research on mental disorders.
      ). This commentary highlights the compatibility of the dimensional approach with extant research on brain and behavioral development and demonstrates how the application of a neurodevelopmental perspective can extend and enrich RDoC.
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      References

        • Insel T.
        • Cuthbert B.
        • Garvey M.
        • Heinssen R.
        • Pine D.S.
        • Quinn K.
        • et al.
        Research domain criteria (RDoc): Toward a new classification framework for research on mental disorders.
        Am J Psychiatry. 2010; 167: 748-751
        • Paus T.
        • Keshavan M.
        • Giedd J.N.
        Why do many psychiatric disorders emerge during adolescence?.
        Nat Rev Neurosci. 2008; 9: 947-957
        • Karmiloff-Smith A.
        • Casey B.J.
        • Massand E.
        • Tomalski P
        • Thomas MSC.
        Environmental and genetic influences on neurocognitive development: The importance of multiple methodologies and time-dependent intervention.
        Clin Psychol Sci. 2014; (doi:10.1177/2167702614521188)
        • Gogtay N.
        • Giedd J.N.
        • Lusk L.
        • Hayashi K.M.
        • Greenstein D.
        • Vaituzis A.C.
        • et al.
        Dynamic mapping of human cortical development during childhood through early adulthood.
        Proc Natl Acad Sci U S A. 2004; 101: 8174-8179
        • Shaw P.
        • Eckstrand K.
        • Sharp W.
        • Blumenthal J.
        • Lerch J.P.
        • Greenstein D.
        • et al.
        Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation.
        Proc Natl Acad Sci U S A. 2007; 104: 19649-19654
        • Shaw P.
        • Gilliam M.
        • Liverpool M.
        • Weddle C.
        • Malek M.
        • Sharp W.
        • et al.
        Cortical development in typically developing children with symptoms of hyperactivity and impulsivity: Support for a dimensional view of attention deficit hyperactivity disorder.
        Am J Psychiatry. 2011; 168: 143-151
        • Pattwell S.S.
        • Duhoux S.
        • Hartley C.A.
        • Johnson D.C.
        • Jing D.
        • Elliott M.D.
        • et al.
        Altered fear leaning across development in both mouse and human.
        Proc Nat Acad Sci U S A. 2012; 109: 16318-16323
        • Drysdale A.T.
        • Hartley C.A.
        • Pattwell S.S.
        • Ruberry E.J.
        • Somerville L.H.
        • Compton S.N.
        • et al.
        Fear and anxiety from principle to practice: Implications for when to treat youth with anxiety disorders.
        Biol Psychiatry. 2014; 75: e19-e20
        • Geschwind D.H.
        • Levitt P.
        Autism spectrum disorders: Developmental disconnection syndromes.
        Curr Opin Neurobiol. 2007; 17: 103-111
        • Casey B.J.
        • Durston S.
        From behavior to cognition to the brain and back: What have we learned from functional imaging studies of attention deficit hyperactivity disorder?.
        Am J Psychiatry. 2006; 163: 957-960