Key Words
MHCI in the Immune System
MHCI in the CNS
MHCI and MHCI Receptor Expression
MHCI and Neuronal Differentiation
MHCI and Synapse Formation
MHCI and Synaptic Function
MHCI and Synaptic Plasticity
MHCI and Activity-Dependent Refinement of Connections
MHCI and Environmental Risk Factors for SZ
Concluding Remarks
References
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- Is There a Flame in the Brain in Psychosis?Biological PsychiatryVol. 75Issue 4
- PreviewFor many decades, it was believed that the brain was immunologically privileged, hence it was surprising when Shatz and colleagues (1) reported in 2000 that a number of immune proteins (cytokines and major histocompatibility complex [MHC] proteins) were not just present in the brain but were localized at functional synapses. Subsequent work has shown that these molecules play a major role in brain development as well as in mature synaptic function and plasticity (2,3).
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