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ADH1B Arg48His Allele Frequency Map: Filling in the Gap for Central Europe

Published:September 09, 2013DOI:https://doi.org/10.1016/j.biopsych.2013.05.042
      A report in Biological Psychiatry described the distribution of the functional variant Arg48His (rs1229984), which is located in the ADH1B gene and protects against alcohol dependence (
      • Li D.
      • Zhao H.
      • Gelernter J.
      Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases.
      ). The authors presented a world map to indicate the frequency of the Arg48His variant in cases and controls from various geographic regions. This map did not include data for Central Europe. In the HapMap subsample of Utah residents with ancestry from northern and western Europe, rs1229984 was monomorphic (http://www.hapmap.org).
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