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Reply to: Effects of Lithium on Magnetic Resonance Imaging Signal Might Not Preclude Increases in Brain Volume After Chronic Lithium Treatment

Published:September 03, 2013DOI:https://doi.org/10.1016/j.biopsych.2013.07.023
      We thank Hajek and Vernon for their informed appraisal of our article (
      • Cousins D.A.
      • Aribisala B.
      • Ferrier I.N.
      • Blamire A.M.
      Lithium, gray matter and magnetic resonance signal.
      ) in which they acknowledge that lithium might alter image contrast but argue that this does not preclude an increase in brain volume after chronic treatment. Their stance is valid, but we submit that a tangible increase in brain volume is neither necessary nor sufficient to account for the imaging findings.
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      References

        • Cousins D.A.
        • Aribisala B.
        • Ferrier I.N.
        • Blamire A.M.
        Lithium, gray matter and magnetic resonance signal.
        Biol Psychiatry. 2013; 73: 652-657
        • Licht R.W.
        • Larsen J.O.
        • Smith D.
        • Braendgaard H.
        Effect of chronic lithium treatment with or without haloperidol on number and size of neurons in the rat neocortex.
        Psychopharmacology. 1994; 115: 371-437
        • Licht R.W.
        • Larsen J.O.
        • Smith D.
        • Braendgaard H.
        Chronic lithium treatment with or without haloperidol fails to affect the morphology of the rat cerebellum.
        Eur Neuropsychopharmacol. 2003; 13: 173-176
        • Vernon A.C.
        • Natesan S.
        • Crum W.R.
        • Cooper J.D.
        • Modo M.
        • Williams S.C.
        • et al.
        Contrasting effects of haloperidol and lithium on rodent brain structure: A magnetic resonance imaging study with postmortem confirmation.
        Biol Psychiatry. 2012; 71: 855-863
        • Birch N.J.
        Lithium accumulation in bone after oral administration in rat and in man.
        Clin Sci Mol Med. 1974; 46: 409-413
        • Birch N.J.
        • Jenner F.A.
        The distribution of lithium and its effects on the distribution and excretion of other ions in the rat.
        Br J Pharmacol. 1973; 47: 586-594
        • Xu J.
        • Culman J.
        • Blume A.
        • Brecht S.
        • Gohlke P.
        Chronic treatment with a low dose of lithium protects the brain against ischaemic injury by reducing apoptotic death.
        Stroke. 2003; 34: 1287-1292
        • Pouladi M.A.
        • Brillaud E.
        • Xie Y.
        • Conforti P.
        • Graham R.K.
        • Dagmar E.
        • et al.
        NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease.
        Neurobiol Dis. 2012; 48: 282-289
        • Nunes M.A.
        • Viel T.A.
        • Buck H.S.
        Microdose lithium treatment stabilised cognitive impairment in patients with Alzheimer’s disease.
        Curr Alzheimer Res. 2013; 10: 104-107
        • Walterfang M.
        • Wood A.G.
        • Barton S.
        • Velakoulis D.
        • Chen J.
        • Reutens D.C.
        • et al.
        Corpus callosum size and shape alterations in individuals with bipolar disorder and their first degree relatives.
        Prog Neuropsychopharmacol Biol Psychiatry. 2009; 33: 1050-1057
        • Monkul E.S.
        • Matsuo K.
        • Nicoletti M.A.
        • Dierschke N.
        • Hatch J.P.
        • Dalwani M.
        • et al.
        Prefrontal grey matter increases in healthy individuals after lithium treatment: A voxel-based morphometry study.
        Neurosci Lett. 2007; 429: 7-11
        • Hajek T.
        • Mauer M.
        • Pfennig A.
        • Cullis J.
        • Ploch J.
        • O’Donovan C.
        • et al.
        Large positive effect of lithium on prefrontal N-acetylaspartate in patients with bipolar disorder: 2-centre study.
        J Psychiatry Neurosci. 2012; 37: 185-192
        • Komoroski R.
        • Pearce J.M.
        • Newton J.E.
        The distribution of lithium in rat brain and muscle in vivo by 7Li NMR imaging.
        Magn Reson Med. 1997; 38: 275-278

      Linked Article

      • Effects of Lithium on Magnetic Resonance Imaging Signal Might Not Preclude Increases in Brain Volume After Chronic Lithium Treatment
        Biological PsychiatryVol. 74Issue 12
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          We read with great interest the thoughtful recent article in which Cousins et al. (1) suggested that the structural brain changes associated with lithium (Li) treatment might not be physical increases in brain volume but rather an artifact caused by shortening of the gray matter (GM) T1 relaxation times by Li. We agree that interpretation of clinical neuroimaging studies investigating the effects of Li on brain structure is unclear, particularly as to the factors underlying potential GM changes. However, although Li treatment might alter contrast in T1 weighted magnetic resonance (MR) images, we here advance clinical and preclinical evidence why this might not preclude a tangible change in brain volume.
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