Innovations in our capacity to image the fine structure of the human brain are urgently
needed because after more than a century of research into the biology of schizophrenia,
we still find ourselves far from understanding the neurobiological mechanisms responsible
for the disorder. Without such an understanding, we are unlikely to discover more
effective ways of preventing or reversing the underlying pathology. In this issue
of Biological Psychiatry, Du et al. (
1
) describe the use of two in magnetic resonance (MR)-based technologies that, when
used in combination, allowed them to make specific references about the nature of
white matter abnormalities in patients with schizophrenia.To read this article in full you will need to make a payment
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References
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Article info
Publication history
Accepted:
July 11,
2013
Received:
July 10,
2013
Identification
Copyright
© 2013 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
ScienceDirect
Access this article on ScienceDirectLinked Article
- Myelin and Axon Abnormalities in Schizophrenia Measured with Magnetic Resonance Imaging TechniquesBiological PsychiatryVol. 74Issue 6
- PreviewIn schizophrenia (SZ), disturbances in integration of activity among brain regions seem to be as important as abnormal activity of any single region. Brain regions are connected through white matter (WM) tracts, and diffusion tensor imaging has provided compelling evidence for WM abnormalities in SZ. However, diffusion tensor imaging alone cannot currently pinpoint the biological basis of these abnormalities.
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