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Diving Deep into White Matter to Improve Our Understanding of the Pathophysiology of Schizophrenia

  • Will J. Cronenwett
    Correspondence
    Address correspondence to Will J. Cronenwett, M.D., 446 E. Ontario Street, Suite 6-200, Chicago, IL 60660
    Affiliations
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Stone Institute of Psychiatry, Northwestern Memorial Hospital, Chicago, Illinois
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  • John G. Csernansky
    Affiliations
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Stone Institute of Psychiatry, Northwestern Memorial Hospital, Chicago, Illinois
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      Innovations in our capacity to image the fine structure of the human brain are urgently needed because after more than a century of research into the biology of schizophrenia, we still find ourselves far from understanding the neurobiological mechanisms responsible for the disorder. Without such an understanding, we are unlikely to discover more effective ways of preventing or reversing the underlying pathology. In this issue of Biological Psychiatry, Du et al. (
      • Du F.
      • Cooper A.J.
      • Thida T.
      • Shinn A.K.
      • Cohen B.M.
      • Ongür D.
      Myelin and axon abnormalities in schizophrenia measured with magnetic resonance imaging techniques.
      ) describe the use of two in magnetic resonance (MR)-based technologies that, when used in combination, allowed them to make specific references about the nature of white matter abnormalities in patients with schizophrenia.
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