Six years ago, at the first Cognitive Neuroscience Treatment Research to Improve Cognition
in Schizophrenia (CNTRICS) meeting, a neuroscientist questioned whether attention
dysfunction was malleable in schizophrenia, despite a recent report that patients
were 5 times more likely to work when cognitive remediation was combined with supported
employment (
1
). The idea that impaired neural systems could demonstrate learning-induced plasticity
was not part of the biological research lexicon at that point in time. Experimental
neuroscientists were rightfully skeptical of a broad array of cognitive remediation
interventions that were often studied under nonblinded and variously controlled conditions.
Perplexing, also, was the homogeneity of effect sizes, despite widely varying treatment
approaches, outcome measures, and length of intervention.To read this article in full you will need to make a payment
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References
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Article info
Publication history
Accepted:
March 21,
2013
Received:
March 20,
2013
Identification
Copyright
Published by Elsevier Inc.
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Access this article on ScienceDirectLinked Article
- Brain Effects of Cognitive Remediation Therapy in Schizophrenia: A Structural and Functional Neuroimaging StudyBiological PsychiatryVol. 73Issue 10
- PreviewCognitive remediation therapy positively affects cognition and daily functioning in patients with schizophrenia. However, studies on the underlying neurobiological mechanisms of this treatment are scarce. The aim of the current study was to investigate functional and structural connectivity brain changes in schizophrenia patients after cognitive remediation therapy using a whole-brain approach that combined functional magnetic resonance imaging and diffusion tensor imaging.
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