Six years ago, at the first Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) meeting, a neuroscientist questioned whether attention dysfunction was malleable in schizophrenia, despite a recent report that patients were 5 times more likely to work when cognitive remediation was combined with supported employment (
1). The idea that impaired neural systems could demonstrate learning-induced plasticity was not part of the biological research lexicon at that point in time. Experimental neuroscientists were rightfully skeptical of a broad array of cognitive remediation interventions that were often studied under nonblinded and variously controlled conditions. Perplexing, also, was the homogeneity of effect sizes, despite widely varying treatment approaches, outcome measures, and length of intervention.
- McGurk S.R.
- Mueser K.T.
- Feldman K.
- Wolfe R.
- Pascaris A.
Cognitive training for supported employment: 2-3 year outcomes of a randomized controlled trial.
Am J Psychiatry. 2007; 164: 437-441
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- Cognitive training for supported employment: 2-3 year outcomes of a randomized controlled trial.Am J Psychiatry. 2007; 164: 437-441
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Accepted: March 21, 2013
Received: March 20, 2013
Published by Elsevier Inc.
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- Brain Effects of Cognitive Remediation Therapy in Schizophrenia: A Structural and Functional Neuroimaging StudyBiological PsychiatryVol. 73Issue 10
- PreviewCognitive remediation therapy positively affects cognition and daily functioning in patients with schizophrenia. However, studies on the underlying neurobiological mechanisms of this treatment are scarce. The aim of the current study was to investigate functional and structural connectivity brain changes in schizophrenia patients after cognitive remediation therapy using a whole-brain approach that combined functional magnetic resonance imaging and diffusion tensor imaging.