Gin and Juice: Modafinil Tightens Up the Drinker's Brain at Rest

  • Michael J. Minzenberg
    Address correspondence to Michael J. Minzenberg, M.D., Outpatient Mental Health, 116C, SF Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121
    Department of Psychiatry, University of California, San Francisco
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      You know Tommy. He’s the guy who closes Trees Lounge at 2 am (always gets the last pour), yet somehow makes it back by 6 am for his daily eye-opener. What happens when Tommy gets some “juice” to go with his steady diet of ethanol? Well, it looks like his neural networks get tightened up considerably, and this may be very good news for his mind and brain (not to mention his family and his employer).
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      Linked Article

      • Modafinil Modulates Resting-State Functional Network Connectivity and Cognitive Control in Alcohol-Dependent Patients
        Biological PsychiatryVol. 73Issue 8
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          Chronic alcohol abuse is associated with deficits in cognitive control functions. Cognitive control is likely to be mediated through the interaction between intrinsic large-scale brain networks involved in externally oriented executive functioning and internally focused thought processing. Improving the interaction between these functional brain networks could be an important target for treatment. Therefore, the current study aimed to investigate the effects of the cognitive enhancer modafinil on within-network and between-network resting-state functional connectivity and cognitive control functions in alcohol-dependent patients.
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