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Contribution of Common Genetic Variants to Antidepressant Response

Published:December 12, 2012DOI:https://doi.org/10.1016/j.biopsych.2012.10.030

      Background

      Pharmacogenetic studies aiming to personalize the treatment of depression are based on the assumption that response to antidepressants is a heritable trait, but there is no compelling evidence to support this.

      Methods

      We estimate the contribution of common genetic variation to antidepressant response with Genome-Wide Complex Trait Analysis in a combined sample of 2799 antidepressant-treated subjects with major depressive disorder and genome-wide genotype data.

      Results

      We find that common genetic variants explain 42% (SE = .180, p = .009) of individual differences in antidepressant response.

      Conclusions

      These results suggest that response to antidepressants is a complex trait with substantial contribution from a large number of common genetic variants of small effect.

      Key Words

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