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Contribution of Common Genetic Variants to Antidepressant Response

Published:December 12, 2012DOI:https://doi.org/10.1016/j.biopsych.2012.10.030

      Background

      Pharmacogenetic studies aiming to personalize the treatment of depression are based on the assumption that response to antidepressants is a heritable trait, but there is no compelling evidence to support this.

      Methods

      We estimate the contribution of common genetic variation to antidepressant response with Genome-Wide Complex Trait Analysis in a combined sample of 2799 antidepressant-treated subjects with major depressive disorder and genome-wide genotype data.

      Results

      We find that common genetic variants explain 42% (SE = .180, p = .009) of individual differences in antidepressant response.

      Conclusions

      These results suggest that response to antidepressants is a complex trait with substantial contribution from a large number of common genetic variants of small effect.

      Key Words

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      Linked Article

      • Antidepressant Response and Polygenes
        Biological PsychiatryVol. 73Issue 7
        • Preview
          The goal of pharmacogenetics, to tailor drug treatments to patients based on molecular genetic markers, is fundamentally premised on drug responses being heritable traits. For studies of disease risk, the traditional genetic-epidemiologic approaches of twin and family studies have convincingly demonstrated a heritable basis for most diseases, motivating subsequent waves of molecular genetic studies to detect the specific genes. However, whether an individual’s response to a given drug is heritable has not, in general, been established.
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