Recognition memory judgments can be based on recollection of qualitative information
about an earlier study event or on assessments of stimulus familiarity. Schizophrenia
is associated with pronounced deficits in overall recognition memory, and these deficits
are highly predictive of global functioning. However, the extent to which these deficits
reflect impairments in recollection or familiarity is less well understood. In the
current article, we reviewed studies that used remember-know-new, process dissociation,
and receiver operating characteristic procedures to investigate recollection and familiarity
in schizophrenia. We also performed a quantitative reanalysis of these study results
to obtain recollection and familiarity estimates that account for methodological differences
between studies. Contrary to previous conclusions that recollection is selectively
impaired in schizophrenia, we found evidence for both familiarity and recollection
deficits across studies, suggesting multi-focal medial temporal lobe and/or prefrontal
cortex dysfunction. The familiarity deficits were more variable with frequent small-to-medium
rather than medium-to-large effect sizes, suggesting that familiarity could be potentially
used as a compensatory ability, whereas recollection is conceptualized as a therapeutic
target for new treatment development.
Key Words
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References
- Memory impairment in schizophrenia: A meta-analysis.Am J Psychiatry. 1999; 156: 1358-1366
- Forms of memory failure in schizophrenia.J Abnorm Psychol. 1992; 101: 487-494
- Memory in schizophrenia: What is impaired and what is preserved?.Neuropsychologia. 1993; 31: 1225-1241
- What are the functional consequences of neurocognitive deficits in schizophrenia?.Am J Psychiatry. 1996; 153: 321-330
- Predictive values of neurocognition and negative symptoms on functional outcome in schizophrenia: A longitudinal first-episode study with 7-year follow-up.Am J Psychiatry. 2005; 162: 495-506
- Impaired generation and use of strategy in schizophrenia: Evidence from visuospatial and verbal tasks.Psychol Med. 1998; 28: 1049-1062
- Is associative recognition more impaired than item recognition memory in schizophrenia? A meta-analysis.Brain Cogn. 2003; 53: 121-124
- The cognitive neuroscience of memory function and dysfunction in schizophrenia.Biol Psychiatry. 2008; 64: 18-25
- A propositional theory of recognition memory.Mem Cognit. 1974; 2: 406-412
- Functional mechanisms underlying impaired recognition memory and conscious awareness in patients with schizophrenia.Arch Gen Psychiatry. 1999; 56: 639-644
- Impairment of constructive memory in schizophrenia.Int Clin Psychopharmacol. 2002; 17: 127-133
- Investigation of conscious recollection, false recognition and delusional misidentification in patients with schizophrenia.Psychopathology. 2003; 36: 312-319
- Auditory recognition memory, conscious recollection, and executive function in patients with schizophrenia.Psychopathology. 2006; 39: 199-208
- Episodic memory in schizophrenia: The influence of strategy use on behavior and brain activation.Psychiatry Res. 2008; 164: 1-15
- Remember and know judgments during recognition in chronic schizophrenia.Schizophr Res. 2008; 100: 181-190
- Episodic memory and impairment of an early encoding process in schizophrenia.Neuropsychology. 2010; 24: 101-108
- Impairment of recognition memory with, but not without, conscious recollection in schizophrenia.Am J Psychiatry. 1995; 152: 1737-1742
- Specificity deficit in the recollection of emotional memories in schizophrenia.Conscious Cogn. 2007; 16: 469-484
- Contributions of the medial temporal lobe to declarative memory retrieval: Manipulating the amount of contextual retrieval.Learn Mem. 2008; 15: 611-617
- Impaired strategic regulation of contents of conscious awareness in schizophrenia.Conscious Cogn. 2003; 12: 190-200
- Subjective qualities of memories associated with the picture superiority effect in schizophrenia.J Abnorm Psychol. 2003; 112: 152-158
- Impairment not only in remembering but also in knowing previously seen faces and words in schizophrenia.Psychiatry Res. 2011; 188: 18-23
- Do patients with schizophrenia consciously recollect emotional events better than neutral events?.Am J Psychiatry. 2003; 160: 1879-1881
- Assessing a minimal executive operation in schizophrenia.Psychiatry Res. 2005; 137: 37-48
- Neural correlates of relational and item-specific encoding during working and long-term memory in schizophrenia.Neuroimage. 2012; 59: 1719-1726
- Relational and Item-Specific Encoding (RISE): Task development and psychometric characteristics.Schizophr Bull. 2012; 38: 114-124
- Recollection and familiarity in negative schizophrenia.Neuropsychologia. 2006; 44: 430-435
- Use of the process dissociation procedure to study the contextual effects on face recognition in schizophrenia: Familiarity, associative recollection and discriminative recollection.Psychiatry Res. 2007; 149: 105-119
- Components of episodic memory: The contribution of recollection and familiarity.Philos Trans R Soc Lond B Biol Sci. 2001; 356: 1363-1374
- Models of recognition: A review of arguments in favor of a dual-process account.Psychon Bull Rev. 2006; 13: 1-21
- Imaging recollection and familiarity in the medial temporal lobe: A three-component model.Trends Cogn Sci. 2007; 11: 379-386
- The role of recollection and familiarity in the functional differentiation of the medial temporal lobes.Hippocampus. 2010; 20: 1291-1314
- The medial temporal lobe and recognition memory.Annu Rev Neurosci. 2007; 30: 123-152
- Recognition memory: What are the roles of the perirhinal cortex and hippocampus?.Nat Rev Neurosci. 2001; 2: 51-61
- Memory and consciousness.Can Psychol. 1985; 26: 1-12
- Receiver-operating characteristics in recognition memory: Evidence for a dual-process model.J Exp Psychol Learn Mem Cogn. 1994; 20: 1341-1354
- The contribution of recollection and familiarity to recognition and source-memory judgments: A formal dual-process model and an analysis of receiver operating characteristics.J Exp Psychol Learn Mem Cogn. 1999; 25: 1415-1434
- A process dissociation framework: Separating automatic from intentional uses of memory.J Mem Lang. 1991; 30: 513-541
- The relation between remembering and knowing as bases for recognition: Effects of size congruency.J Mem Lang. 1995; 34: 622-643
- Memory and metamemory in schizophrenia: A liberal acceptance account of psychosis.Psychol Med. 2008; 38: 825-832
- Recollection and familiarity deficits in amnesia: Convergence of remember-know, process dissociation, and receiver operating characteristic data.Neuropsychology. 1998; 12: 323-339
- Effects of extensive temporal lobe damage or mild hypoxia on recollection and familiarity.Nat Neurosci. 2002; 5: 1236-1241
- Damage to the lateral prefrontal cortex impairs familiarity but not recollection.Behav Brain Res. 2011; 225: 297-304
- Receiver operating characteristics (ROCs) in recognition memory: A review.Psychol Bull. 2007; 133: 800-832
- Context memory and binding in schizophrenia.Schizophr Res. 2004; 68: 119-125
- Dissociating automatic and controlled processes in a memory-search task: Beyond implicit memory.Psychol Res. 1995; 57: 156-165
- Item, context and relational episodic encoding in humans.Curr Opin Neurobiol. 2006; 16: 693-700
- Dissociable correlates of recollection and familiarity within the medial temporal lobes.Neuropsychologia. 2004; 42: 2-13
- The roles of perirhinal cortex, postrhinal cortex, and the fornix in memory for objects, contexts, and events in the rat.Q J Exp Psychol B. 2005; 58: 202-217
- An animal model of amnesia that uses Receiver Operating Characteristics (ROC) analysis to distinguish recollection from familiarity deficits in recognition memory.Neuropsychologia. 2010; 48: 2281-2289
- The hippocampal/parahippocampal regions and recognition memory: Insights from visual paired comparison versus object-delayed nonmatching in monkeys.J Neurosci. 2004; 24: 2013-2026
- Memory for spatial location and object-place associations are differently processed by the hippocampal formation, parahippocampal areas TH/TF and perirhinal cortex.Hippocampus. 2008; 18: 64-80
- Effects of unilateral prefrontal lesions on familiarity, recollection, and source memory.J Neurosci. 2005; 25: 8333-8337
- Remembering and knowing in patients with frontal lobe injuries.Cortex. 2003; 39: 827-846
- The role of the prefrontal cortex in familiarity and recollection processes during verbal and non-verbal recognition memory: An rTMS study.Neuroimage. 2010; 52: 348-357
- Event-related fMRI studies of episodic encoding and retrieval: Meta-analyses using activation likelihood estimation.Neuropsychologia. 2009; 47: 1765-1779
- Prefrontal activation deficits during episodic memory in schizophrenia.Am J Psychiatry. 2009; 166: 863-874
- Hippocampal and parahippocampal volumes in schizophrenia: A structural MRI study.Schizophr Bull. 2006; 32: 332-340
- Medial temporal lobe structure and cognition in individuals with schizophrenia and in their non-psychotic siblings.Schizophr Res. 2012; 138: 128-135
- Decrements in volume of anterior ventromedial temporal lobe and olfactory dysfunction in schizophrenia.Arch Gen Psychiatry. 2003; 60: 1193-1200
- Metamemory knowledge and beliefs in patients with schizophrenia and how these relate to objective cognitive abilities.Conscious Cogn. 2011; 20: 1315-1326
- The development of recollection and familiarity in childhood and adolescence: Evidence from the dual-process signal detection model.Child Dev. 2008; 79: 339-358
- Recollection training and transfer effects in older adults: Successful use of a repetition-lag procedure.Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2005; 12: 278-298
- Improving memory in older adults: Training recollection.Neuropsychol Rehabil. 2003; 13: 417-440
- On the prediction of occurrence of particular verbal intrusions in immediate recall.J Exp Psychol. 1959; 58: 17-22
- Creating false memories: Remembering words not presented in lists.J Exp Psychol Learn Mem Cogn. 1995; 21: 803-814
Article info
Publication history
Published online: December 17, 2012
Accepted:
October 31,
2012
Received in revised form:
October 26,
2012
Received:
July 31,
2012
Identification
Copyright
© 2013 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
