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Emotional Reactivity and Regulation in Panic Disorder: Insights from a Functional Magnetic Resonance Imaging Study of Cognitive Behavioral Therapy

      For more than a century, psychologists and psychiatrists have sought to understand the biological bases of mental disorders, with a view to fashioning more effective treatments. Advances in functional neuroimaging have made it possible for clinical researchers to make significant strides towards realizing this long-held goal, allowing them to do the following: 1) characterize differences in neural responses between patients with various psychiatric conditions and healthy subjects (HS), and 2) examine the neural correlates of psychosocial and biologic treatments.
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      Linked Article

      • Effect of Cognitive-Behavioral Therapy on Neural Correlates of Fear Conditioning in Panic Disorder
        Biological PsychiatryVol. 73Issue 1
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          Learning by conditioning is a key ability of animals and humans for acquiring novel behavior necessary for survival in a changing environment. Aberrant conditioning has been considered a crucial factor in the etiology and maintenance of panic disorder with agoraphobia (PD/A). Cognitive-behavioral therapy (CBT) is an effective treatment for PD/A. However, the neural mechanisms underlying the effects of CBT on conditioning processes in PD/A are unknown.
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