Background
Volume and integrity of white matter correlate with reading ability, but the underlying
factors contributing to this variability are unknown.
Methods
We investigated single nucleotide polymorphisms in three genes previously associated
with dyslexia and implicated in neuronal migration (DYX1C1, DCDC2, KIAA0319) and white matter volume in a cohort of 76 children and young adults from the general
population.
Results
We found that all three genes contained polymorphisms that were significantly associated
with white matter volume in the left temporo-parietal region and that white matter
volume influenced reading ability.
Conclusions
The identified region contained white matter pathways connecting the middle temporal
gyrus with the inferior parietal lobe. The finding links previous neuroimaging and
genetic results and proposes a mechanism underlying variability in reading ability
in both normal and impaired readers.
Key Words
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Article info
Publication history
Published online: June 11, 2012
Accepted:
May 4,
2012
Received in revised form:
April 27,
2012
Received:
October 28,
2011
Identification
Copyright
© 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
