Posttraumatic stress disorder (PTSD) is a common, distressing, and debilitating consequence of the experience of extremely stressful life events, exemplified by combat, sexual assault, torture, or natural disasters. Although the majority of people exposed to these extreme events recover within days to months, long-term follow-up of Vietnam Veterans and survivors of the Nazi Death Camps indicate that for many traumatized people, symptoms persist for decades, perhaps for the rest of their lives (
- Kulka R.
- Schlenger W.
- Fairbank J.
- Hough R.
- Jordan B.
- Marmar C.
Trauma and the Vietnam War Generation: Report of Findings from the National Vietnam Veterans Readjustment Study.
Brunner Mazel, New York1990
2). The very persistence of the impact of what can be a single life experience suggests that traumatization profoundly engages neuroplasticity mechanisms. In addition, compromised neuroplasticity may be a factor preventing individuals with PTSD from benefiting from available social supports and from psychotherapies and pharmacotherapies for PTSD.
- Joffe C.
- Brodaty H.
- Luscombe G.
- Ehrlich F.
The Sydney Holocaust study: posttraumatic stress disorder and other psychosocial morbidity in an aged community sample.
J Trauma Stress. 2003; 16: 39-47
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Biological Psychiatry
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Trauma and the Vietnam War Generation: Report of Findings from the National Vietnam Veterans Readjustment Study.Brunner Mazel, New York1990
- The Sydney Holocaust study: posttraumatic stress disorder and other psychosocial morbidity in an aged community sample.J Trauma Stress. 2003; 16: 39-47
- A randomized placebo-controlled trial of D-cycloserine to enhance exposure therapy for posttraumatic stress disorder.Biol Psychiatry. 2012; 71: 962-968
- Pilot-controlled trial of D-cycloserine for the treatment of post-traumatic stress disorder.Int J Neuropsychopharmacol. 2002; 5: 301-307
- Effects of D-cycloserine on extinction: translation from preclinical to clinical work.Biol Psychiatry. 2006; 60: 369-375
- A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy.Biol Psychiatry. 2008; 63: 1118-1126
- D-cycloserine attenuates reactivity to smoking cues in nicotine dependent smokers: a pilot investigation.Drug Alcohol Depend. 2009; 104: 220-227
- IV glycine and oral D-cycloserine effects on plasma and CSF amino acids in healthy humans.Biol Psychiatry. 2000; 47: 450-462
- Behavioural neuroscience: the circuit of fear.Nature. 2008; 454: 589-590
- Augmentation of fear extinction by D-cycloserine is blocked by proteasome inhibitors.Neuropsychopharmacology. 2008; 33: 3085-3095
Accepted: March 23, 2012
Received: March 19, 2012
© 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
ScienceDirectAccess this article on ScienceDirect
- A Randomized Placebo-Controlled Trial of d-Cycloserine to Enhance Exposure Therapy for Posttraumatic Stress DisorderBiological PsychiatryVol. 71Issue 11
- PreviewPosttraumatic stress disorder (PTSD) is a complex and debilitating anxiety disorder, and, although prolonged exposure therapy has been proven effective, many patients remain symptomatic after treatment. In other anxiety disorders, the supplementary use of d-cycloserine (DCS), a partial agonist at the glutamatergic N-methyl-D-aspartate receptor, showed promise in enhancing treatment effects. We examined whether augmentation of prolonged exposure therapy for PTSD with DCS enhances treatment efficacy.