Commentary| Volume 71, ISSUE 10, P844-845, May 15, 2012

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Functional Network Endophenotypes of Psychotic Disorders

  • Ed Bullmore
    Address correspondence to Ed Bullmore, Ph.D., Behavioural and Clinical Neuroscience Institute, Department of Psychiatry, University of Cambridge, Herchel Smith Building for Brain and Mind Sciences, Cambridge Biomedical Campus, Cambridge CB2 0SZ, United Kingdom
    Behavioural and Clinical Neuroscience Institute, Department of Psychiatry, University of Cambridge; and Cambridgeshire & Peterborough NHS Foundation Trust, Cambridge, United Kingdom
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      One of the pivotal diagnostic distinctions in psychiatry is between bipolar disorder and schizophrenia. Manic depressive psychosis was distinguished from psychosis in general in the 19th century and, following Kraepelin's work in the early 20th century, schizophrenia was differentiated in terms of its phenomenology and natural history. Although this clinical compartmentalization of psychosis has been useful and enduring, there is increasing evidence that under the hood of the classically different phenotypes there may be more in common between bipolar disorder and schizophrenia than a strict Kraepelinian dichotomy would predict (
      • Craddock N.
      • Owen M.J.
      The Kraeplinian dichotomy—going, going … but still not gone.
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