Genome-wide association studies of psychiatric disorders have been criticized for
their lack of explaining a considerable proportion of the heritability established
in twin and family studies. Genome-wide association studies of major depressive disorder
in particular have so far been unsuccessful in detecting genome-wide significant single
nucleotide polymorphisms (SNPs). Using two recently proposed methods designed to estimate
the heritability of a phenotype that is attributable to genome-wide SNPs, we show
that SNPs on current platforms contain substantial information concerning the additive
genetic variance of major depressive disorder. To assess the consistency of these
two methods, we analyzed four other complex phenotypes from different domains. The
pattern of results is consistent with estimates of heritability obtained in twin studies
carried out in the same population.
Key Words
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Article info
Publication history
Published online: April 23, 2012
Accepted:
March 11,
2012
Received in revised form:
February 25,
2012
Received:
May 4,
2011
Identification
Copyright
© 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
