Social integration in general and pair-bond relationships in particular are important predictors of individual health and longevity (
1). It is therefore of the greatest research interest to investigate the underlying neurobiological mechanisms that might mediate the associations of pair-bond relationships and health. Recent research has suggested a prominent role of the neuropeptide oxytocin in this complex relationship and oxytocin is assumed to mediate the effects of couple interaction on stress reduction and individual health in the long term (e.g., [
- Holt-Lunstad J.
- Smith T.B.
- Layton J.B.
Social relationships and mortality risk: a meta-analytic review.
PLoS Med. 2010; 7: e1000316
2], for reviews see [
- Ditzen B.
- Schaer M.
- Bodenmann G.
- Gabriel B.
- Ehlert U.
- Heinrichs M.
Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict.
Biol Psychiatry. 2009; 65: 728-731
- Insel T.R.
The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior.
Neuron. 2010; 65: 768-779
- Ross H.E.
- Young L.J.
Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior.
Front Neuroendocrinol. 2009; 30: 534-547
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- Social relationships and mortality risk: a meta-analytic review.PLoS Med. 2010; 7: e1000316
- Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict.Biol Psychiatry. 2009; 65: 728-731
- The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior.Neuron. 2010; 65: 768-779
- Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior.Front Neuroendocrinol. 2009; 30: 534-547
- Variation in the oxytocin receptor gene is associated with pair-bonding and social behavior.Biol Psychiatry. 2012; 71: 419-426
- Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine.Nat Rev Neurosci. 2011; 12: 524-538
- Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans.Proc Natl Acad Sci USA. 2009; 106: 21437-21441
- Oxytocin receptor gene (OXTR) is related to psychological resources.Proc Natl Acad Sci USA. 2011; 108: 15118-15122
- Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans.Proc Natl Acad Sci USA. 2011; 108: 19937-19942
- Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults.JAMA. 2008; 299: 1291-1305
- Association between childhood maltreatment and adult emotional dysregulation in a low-income, urban, African American sample: moderation by oxytocin receptor gene.Dev Psychopathol. 2011; 23: 87-100
- Sensitivity to intranasal oxytocin in adult men with early parental separation.Biol Psychiatry. 2007; 61: 1109-1111
- Beyond satisfaction: the role of attachment in marital functioning.J Fam Theory Rev. 2010; 2: 258-279
- Emotion dysregulation and negative affect: association with psychiatric symptoms.J Clin Psychiatry. 2011; 72: 685-691
- Clinical assessment of attachment patterns and personality disorder in adolescents and adults.J Consult Clin Psychol. 2006; 74: 1065-1085
Published online: February 27, 2012
© 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.