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Correspondence| Volume 71, ISSUE 8, e35-e37, April 15, 2012

Effective Deep Brain Stimulation in Heroin Addiction: A Case Report with Complementary Intracranial Electroencephalogram

Published:January 27, 2012DOI:https://doi.org/10.1016/j.biopsych.2011.12.013
Effective Deep Brain Stimulation in Heroin Addiction: A Case Report with Complementary Intracranial Electroencephalogram
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      Deep brain stimulation (DBS) treatment consists of permanently implanted electrodes that deliver electrical pulses to a target brain region. DBS of the nucleus accumbens shows encouraging results as treatment for certain therapy-resistant psychiatric disorders (
      • Goodman W.K.
      • Alterman R.L.
      Deep brain stimulation for intractable psychiatric disorders.
      Annu Rev Med. 2011; ([published online ahead of print January 26])
      ,
      • Denys D.
      • Mantione M.
      • Figee M.
      • van den Munckhof P.
      • Koerselman F.
      • Westenberg H.
      • et al.
      Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder.
      Arch Gen Psychiatry. 2010; 67: 1061-1068
      ) and has been suggested for therapy-resistant addiction (
      • Luigjes J.
      • van den Brink W.
      • Feenstra M.
      • van den Munckhof P.
      • Schuurman P.R.
      • Schippers R.
      • et al.
      Deep brain stimulation in addiction: A review of potential brain targets.
      Mol Psychiatry. 2011; ([published online ahead of print September 20])
      ). Heroin addiction is a chronic relapsing brain disorder seriously affecting both the individual and the public (
      • Hser Y.I.
      • Hoffman V.
      • Grella C.E.
      • Anglin M.D.
      A 33-year follow-up of narcotics addicts.
      Arch Gen Psychiatry. 2001; 58: 503-508
      ), and DBS could provide a new intervention for those patients who do not respond to current treatments. One central issue in DBS treatment is adaptation of the stimulation parameters: to achieve effective DBS treatment, an extensive optimization period is required in which stimulation parameters— such as contact points, current, and pulse width—are adapted based on clinical observations.
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      References

        • Goodman W.K.
        • Alterman R.L.
        Deep brain stimulation for intractable psychiatric disorders.
        Annu Rev Med. 2011; ([published online ahead of print January 26])
        View in Article
        • Denys D.
        • Mantione M.
        • Figee M.
        • van den Munckhof P.
        • Koerselman F.
        • Westenberg H.
        • et al.
        Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder.
        Arch Gen Psychiatry. 2010; 67: 1061-1068
        View in Article
        • Luigjes J.
        • van den Brink W.
        • Feenstra M.
        • van den Munckhof P.
        • Schuurman P.R.
        • Schippers R.
        • et al.
        Deep brain stimulation in addiction: A review of potential brain targets.
        Mol Psychiatry. 2011; ([published online ahead of print September 20])
        View in Article
        • Hser Y.I.
        • Hoffman V.
        • Grella C.E.
        • Anglin M.D.
        A 33-year follow-up of narcotics addicts.
        Arch Gen Psychiatry. 2001; 58: 503-508
        View in Article
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      Article info

      Publication history

      Published online: January 27, 2012

      Identification

      DOI: https://doi.org/10.1016/j.biopsych.2011.12.013

      Copyright

      © 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

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