Deep brain stimulation (DBS) treatment consists of permanently implanted electrodes that deliver electrical pulses to a target brain region. DBS of the nucleus accumbens shows encouraging results as treatment for certain therapy-resistant psychiatric disorders (
- Goodman W.K.
- Alterman R.L.
Deep brain stimulation for intractable psychiatric disorders.
Annu Rev Med. 2011; ([published online ahead of print January 26])
2) and has been suggested for therapy-resistant addiction (
- Denys D.
- Mantione M.
- Figee M.
- van den Munckhof P.
- Koerselman F.
- Westenberg H.
- et al.
Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder.
Arch Gen Psychiatry. 2010; 67: 1061-1068
3). Heroin addiction is a chronic relapsing brain disorder seriously affecting both the individual and the public (
- Luigjes J.
- van den Brink W.
- Feenstra M.
- van den Munckhof P.
- Schuurman P.R.
- Schippers R.
- et al.
Deep brain stimulation in addiction: A review of potential brain targets.
Mol Psychiatry. 2011; ([published online ahead of print September 20])
4), and DBS could provide a new intervention for those patients who do not respond to current treatments. One central issue in DBS treatment is adaptation of the stimulation parameters: to achieve effective DBS treatment, an extensive optimization period is required in which stimulation parameters— such as contact points, current, and pulse width—are adapted based on clinical observations.
- Hser Y.I.
- Hoffman V.
- Grella C.E.
- Anglin M.D.
A 33-year follow-up of narcotics addicts.
Arch Gen Psychiatry. 2001; 58: 503-508
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- Deep brain stimulation for intractable psychiatric disorders.Annu Rev Med. 2011; ([published online ahead of print January 26])
- Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder.Arch Gen Psychiatry. 2010; 67: 1061-1068
- Deep brain stimulation in addiction: A review of potential brain targets.Mol Psychiatry. 2011; ([published online ahead of print September 20])
- A 33-year follow-up of narcotics addicts.Arch Gen Psychiatry. 2001; 58: 503-508
- Initial validation of two opiate craving questionnaires: The Obsessive Compulsive Drug Use Scale and the Desires for Drug Questionnaire.Addict Behav. 2002; 27: 675-685
- Functional disconnection of frontal cortex and visual cortex in attention-deficit/hyperactivity disorder.Biol Psychiatry. 2010; 67: 617-623
- Deep brain stimulation of nucleus accumbens on heroin-seeking behaviors: A case report.Biol Psychiatry. 2011; 69: e41-e42
Published online: January 27, 2012
© 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.