Child abuse is a nonspecific risk factor associated with an increased risk for a range
of psychiatric and substance use disorders. The paper in this issue by Dannlowski
et al. (
1
) adds to a growing body of literature on the mechanisms by which adverse early experiences
confer vulnerability to psychiatric illness. The paper by Nikulina et al. (
2
) delineate further genetic and other factors that account for individual differences
in the outcomes of adults who were abused as children.To read this article in full you will need to make a payment
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References
- Limbic scars: long-term consequences of childhood maltreatment revealed by functional and structural magnetic resonance imaging.Biol Psychiatry. 2012; 71: 286-293
- Child abuse and neglect, MAOA, and mental health outcomes: a prospective examination.Biol Psychiatry. 2012; 71: 350-357
- Hippocampal volume deficits associated with exposure to psychological trauma and posttraumatic stress disorder in adults: a meta-analysis.Prog Neuropsychopharmacol Biol Psychiatry. 2010; 34: 1181-1188
- Role of genotype in the cycle of violence in maltreated children.Science. 2002; 297: 851-854
- Developmental psychopathology.in: Martin A. Scahill L. Kratochvil C.J. Neurobiology of Early Life Stress: Evolving Concepts, in Pediatric Psychopharmacology. Oxford University Press, New York2010: 112-123
- Effects of early adverse experience on brain structure and function: clinical implications.Biol Psychiatry. 2000; 48: 778-790
- Developing constructs for psychopathology research: research domain criteria.J Abnorm Psychol. 2010; 119: 631-639
- Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis.Biol Psychiatry. 2008; 63: 852-857
- Epigenome-wide association studies for common human diseases.Nat Rev Genet. 2011; 12: 529-541
- Critical periods revisited: implications for intervention with traumatized children.J Am Acad Child Adolesc Psychiatry. 2011; 50: 1087-1089
Article info
Publication history
Accepted:
December 15,
2011
Received:
December 9,
2011
Identification
Copyright
© 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
ScienceDirect
Access this article on ScienceDirectLinked Article
- Limbic Scars: Long-Term Consequences of Childhood Maltreatment Revealed by Functional and Structural Magnetic Resonance ImagingBiological PsychiatryVol. 71Issue 4
- PreviewChildhood maltreatment represents a strong risk factor for the development of depression and posttraumatic stress disorder (PTSD) in later life. In the present study, we investigated the neurobiological underpinnings of this association. Since both depression and PTSD have been associated with increased amygdala responsiveness to negative stimuli as well as reduced hippocampal gray matter volume, we speculated that childhood maltreatment results in similar functional and structural alterations in previously maltreated but healthy adults.
- Full-Text
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- Child Abuse and Neglect, MAOA, and Mental Health Outcomes: A Prospective ExaminationBiological PsychiatryVol. 71Issue 4
- PreviewStudies have examined the interaction of MAOA genotype with childhood maltreatment in relation to depressive symptomatology and alcohol abuse with conflicting findings. Both high- and low-activity allele combinations have been shown to be protective for maltreated children with direction of findings varying by study methodology and participants' sex.
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