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Correspondence| Volume 71, ISSUE 7, e29-e30, April 01, 2012

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Reply to: Are Antidepressants Good for the Soul but Bad for the Matter? Using Noninvasive Brain Stimulation to Detangle Depression/Antidepressants Effects on Heart Rate Variability and Cardiovascular Risk

  • Andrew H. Kemp
    Correspondence
    Corresponding author
    Affiliations
    School of Psychology, University of Sydney, Sydney, Australia

    CADE Clinic, Discipline of Psychiatry, Sydney Medical School-Northern, University of Sydney, Sydney, Australia
    Search for articles by this author
Published:December 05, 2011DOI:https://doi.org/10.1016/j.biopsych.2011.11.002
      We thank Brunoni et al. (
      • Brunoni A.R.
      • Lotufo P.A.
      • Benseñor I.M.
      Are antidepressants good for the soul but bad for the matter? Using noninvasive brain stimulation to detangle depression/antidepressants effects on heart rate variability and cardiovascular risk.
      ) for their interesting and thoughtful commentary on our review and meta-analysis on heart rate variability (HRV) (
      • Kemp A.H.
      • Quintana D.S.
      • Gray M.A.
      • Felmingham K.L.
      • Brown K.
      • Gatt J.M.
      Impact of depression and antidepressant treatment on heart rate variability: A review and meta-analysis.
      ). Heart rate variability has generated significant interest in the research and clinical communities, because it predicts future mortality (
      • Galinier M.
      • Pathak A.
      • Fourcade J.
      • Androdias C.
      • Curnier D.
      • Varnous S.
      • et al.
      Depressed low frequency power of heart rate variability as an independent predictor of sudden death in chronic heart failure.
      ,
      • Dekker J.M.
      • Crow R.S.
      • Folsom A.R.
      • Hannan P.J.
      • Liao D.
      • Swenne C.A.
      • et al.
      Low heart rate variability in a 2-minute rhythm strip predicts risk of coronary heart disease and mortality from several causes: The ARIC Study Atherosclerosis Risk In Communities.
      ) and might underlie the poor social functioning observed in a variety of psychiatric disorders (
      • Porges S.W.
      The Polyvagal Theory: Neurophysiological Foundations of Emotions, Attachment, Communication, and Self-regulation.
      ), including major depressive disorder (MDD).
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