We thank Brunoni et al. (
1
) for their interesting and thoughtful commentary on our review and meta-analysis
on heart rate variability (HRV) (
2
). Heart rate variability has generated significant interest in the research and clinical
communities, because it predicts future mortality (
3
,
4
) and might underlie the poor social functioning observed in a variety of psychiatric
disorders (
5
), including major depressive disorder (MDD).To read this article in full you will need to make a payment
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References
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Article info
Publication history
Published online: December 05, 2011
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© 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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- Are Antidepressants Good for the Soul but Bad for the Matter? Using Noninvasive Brain Stimulation to Detangle Depression/Antidepressants Effects on Heart Rate Variability and Cardiovascular RiskBiological PsychiatryVol. 71Issue 7
- PreviewHeart rate variability (HRV) is an electrocardiograph-based technique that assesses sympathovagal activity over the heartbeat. Lower HRV (i.e., low power in the low frequency of the power spectral analysis) has been associated with an increased risk for myocardial infarction (1) and other cardiovascular conditions and thus is a biomarker for cardiac illness. Two articles recently published in Biological Psychiatry showed that lower HRV is observed in major depressive disorder (MDD). However, whereas the meta-analysis of Kemp et al.
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