The study by Escobar et al. (
1
) in this issue shows that exposure of the pregnant rat dam at day 19 of gestation
to a bacterial endotoxin, a manipulation used to model maternal immune activation
(MIA), leads to abnormal postnatal development of synaptic long-term depression (LTD)
in the CA3-CA1 hippocampal circuit in the offspring. The form of LTD they examined
is induced by low-frequency stimulation of the glutamatergic efferents from CA3, which
synapse extensively onto the dendrites of the CA1 projection neurons.To read this article in full you will need to make a payment
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References
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Article info
Publication history
Accepted:
October 3,
2011
Received:
October 3,
2011
Identification
Copyright
© 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
