Advertisement

Attention Bias Modification and the Serotonin Transporter: Personalized Treatment Implications of Gene Interactions with Learning

      Threat-related attention biases play a role in the etiology and maintenance of anxiety (
      • Bar-Haim Y.
      • Lamy D.
      • Pergamin L.
      • Bakermans-Kranenburg M.J.
      • van IJzendoorn M.H.
      Threat-related attentional bias in anxious and nonanxious individuals: a meta-analytic study.
      ). Initial evidence from a recent meta-analysis suggests that attention bias modification (ABM) procedures reduce anxiety by targeting threat biases (
      • Hakamata Y.
      • Lissek S.
      • Bar-Haim Y.
      • Britton J.C.
      • Fox N.A.
      • Leibenluft E.
      • et al.
      Attention bias modification treatment: a meta-analysis toward the establishment of novel treatment for anxiety.
      ). However, questions regarding the clinical applications of ABM procedures still exist. In particular, it remains unclear when attention retraining procedures are effective and translate into therapeutic benefit.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Bar-Haim Y.
        • Lamy D.
        • Pergamin L.
        • Bakermans-Kranenburg M.J.
        • van IJzendoorn M.H.
        Threat-related attentional bias in anxious and nonanxious individuals: a meta-analytic study.
        Psychol Bull. 2007; 133: 1-24
        • Hakamata Y.
        • Lissek S.
        • Bar-Haim Y.
        • Britton J.C.
        • Fox N.A.
        • Leibenluft E.
        • et al.
        Attention bias modification treatment: a meta-analysis toward the establishment of novel treatment for anxiety.
        Biol Psychiatry. 2010; 68: 982-990
        • Fox E.
        • Zougkou K.
        • Ridgewell A.
        • Garner K.
        • et al.
        The serotonin transporter gene alters sensitivity to attention bias modification: evidence for a plasticity gene.
        Biol Psychiatry. 2011; 70: 1049-1054
        • Bakermans-Kranenburg M.J.
        • van IJzendoorn M.H.
        • Pijlman F.T.
        • Mesman J.
        • Juffer F.
        Experimental evidence for differential susceptibility: dopamine D4 receptor polymorphism (DRD4 VNTR) moderates intervention effects on toddlers' externalizing behavior in a randomized controlled trial.
        Dev Psychol. 2008; 44: 293-300
        • Wald I.
        • Shechner T.
        • Bitton S.
        • Holoshitz Y.
        • Charney D.S.
        • Muller D.
        • et al.
        Attention bias away from threat during life threatening danger predicts PTSD symptoms at one-year follow-up.
        Depress Anxiety. 2011; 28: 406-411
        • Browning M.
        • Holmes E.A.
        • Murphy S.E.
        • Goodwin G.M.
        • Harmer C.J.
        Lateral prefrontal cortex mediates the cognitive modification of attentional bias.
        Biol Psychiatry. 2010; 67: 919-925
        • Amir N.
        • Beard C.
        • Taylor C.T.
        • Klumpp H.
        • Elias J.
        • Burns M.
        • et al.
        Attention training in individuals with generalized social phobia: a randomized controlled trial.
        J Consult Clin Psychol. 2009; 77: 961-973
        • Schmidt N.B.
        • Richey J.A.
        • Buckner J.D.
        • Timpano K.R.
        Attention training for generalized social anxiety disorder.
        J Abnorm Psychol. 2009; 118: 5-14
        • Bryant R.A.
        • Felmingham K.L.
        • Falconer E.M.
        • Pe Benito L.
        • Dobson-Stone C.
        • Pierce K.D.
        • et al.
        Preliminary evidence of the short allele of the serotonin transporter gene predicting poor response to cognitive behavior therapy in posttraumatic stress disorder.
        Biol Psychiatry. 2010; 67: 1217-1219

      Linked Article

      • The Serotonin Transporter Gene Alters Sensitivity to Attention Bias Modification: Evidence for a Plasticity Gene
        Biological PsychiatryVol. 70Issue 11
        • Preview
          Attention bias modification (ABM) procedures have been shown to modify biased attention with important implications for emotional vulnerability and resilience. The use of ABM to reduce potentially toxic biases, for instance, is a newly emerging therapy for anxiety disorders. A separate line of gene-by-environment interaction research proposes that many so-called vulnerability genes or risk alleles are better seen as plasticity genes, as they seem to make individuals more susceptible to environmental influences for better and for worse.
        • Full-Text
        • PDF
        Open Access