The fragile X mental retardation 1 protein (FMRP) is a master protein regulating the
transport and subsequent translation of hundreds of messenger ribonucleic acids (mRNAs)
into proteins important for synaptic plasticity that impacts intelligence and emotion
(
1
). FMRP is missing in males with fragile X syndrome (FXS) and sometimes deficient
in carriers and females with FXS. Through evolution the CGG repeat at the 5' end of
FMR1 at Xq27.3 has expanded, leading to increased production of FMRP, which has enhanced
intelligence and emotional functioning in the evolution of humans.To read this article in full you will need to make a payment
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Article info
Publication history
Accepted:
September 14,
2011
Received:
September 14,
2011
Identification
Copyright
© 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
