Schizophrenia: Genetic, Molecular, and Cellular Findings
Recently, the discovery of several novel genes for schizophrenia has provided a solid basis on which to investigate its biological foundations. Here, Ottis et al.
(pages 604–610) report that one of these genes, disrupted-in-schizophrenia 1 (DISC1
), when aggregated as a protein, can segregate with another schizophrenia candidate protein, dysbindin, that previously has not been directly linked to the DISC1 pathway. These investigations suggest that schizophrenia pathology of different, independently identified genes may converge on the protein level.
Schizophrenia susceptibility has been previously linked to neurodevelopmental processes involving tyrosine phosphorylation-mediated signaling. Takahashi et al.
(pages 626–635) performed genetic, behavioral, and postmortem mouse and human studies that implicate the PTPRA
gene, which encodes protein tyrosine phosphatase RPTPα, in schizophrenia. This convergent evidence linking RPTPα to schizophrenia may represent a potential novel avenue for therapeutic exploration, particularly the tyrosine kinases c-Src and Fyn.
Identifying the location of ErbB4, the receptor mediating the biological effects of neuregulin-1, is essential for understanding how this pathway regulates neuronal network activity and behaviors, and its association with psychiatric disorders. Neddens et al.
(pages 636–645) analyzed the cellular and subcellular distribution of ErbB4 in neurons of the frontal cortex of five species. They found that ErbB4 expression is evident in a subset of interneurons, but undetectable in pyramidal neurons of the frontal cortex, validating the use of rodents to study the biological functions of ErbB4.
Sodhi et al.
(pages 646–654) measured the expression of glutamatergic transcripts in two populations of laser-captured cells from the medial dorsal thalamus in postmortem brains of individuals with schizophrenia and psychiatrically healthy controls. They detected reduced glutamatergic gene expression in schizophrenia, specifically in the large medial dorsal cells, which are mostly glutamatergic relay neurons projecting to the prefrontal cortex. These findings indicate that glutamatergic innervation is dysfunctional in the thalamocortical circuitry in schizophrenia.
Buizer-Voskamp et al.
(pages 655–662) investigated the involvement of large genomic deletions and duplications in Dutch schizophrenia patients and healthy controls. They observed significantly more genomic deletions, but not duplications, in patients compared to controls. A subsequent systematic literature search for genomic and cytogenetic variants reported in schizophrenia patients helps highlight potential chromosomal regions of interest.
The major histocompatibility complex (MHC) region plays a central role in the immune system and has been implicated in the development of schizophrenia. Agartz et al.
(pages 696–698) investigated associations between gene variants across the MHC region and brain structure in patients with severe mental illness and healthy controls. They report significant associations in schizophrenia spectrum disorder patients between common gene markers in the MHC region and cerebral ventricular volume, adding evidence to potential immune system involvement in schizophrenia pathology.
Structural Imaging in Schizophrenia
Brain abnormalities are present in individuals with schizophrenia at disease onset, but the progression of these abnormalities over time is less clear. Using data from a longitudinal study of patients with first-episode schizophrenia and controls, Andreasen et al.
(pages 672–679) report that progressive brain change occurs in schizophrenia, affects both gray matter and white matter, is most severe during the early stages of the illness, and occurs only in a subset of patients. Thus, measuring the severity of progressive brain change may offer a promising new avenue for phenotype definition in genetic studies of schizophrenia.
Phillips et al.
(pages 680–689) used a novel structural and diffusion tensor imaging method to assess the integrity of superficial white matter between schizophrenia patients and their relatives and community comparison subjects and their relatives. Compared to controls, patients showed reduced superficial white matter integrity across both hemispheres. Further, integrity of superficial white matter was shown to vary in accordance with relatedness to a schizophrenia patient in both hemispheres indicating disease-related genetic factors.
© 2011 Published by Elsevier Inc. All rights reserved.