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ErbB4 Localization to Interneurons: Clearer Insights into Schizophrenia Pathology

  • Margaret A. Cooper
    Correspondence
    Address correspondence to Margaret A. Cooper, Ph.D., Departments of Molecular Biophysics and Biochemistry and Neurobiology, Yale University, 333 Cedar Street, New Haven, Connecticut 06520-8024
    Affiliations
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut
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  • Anthony J. Koleske
    Affiliations
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut

    Department of Neurobiology, Yale University, New Haven, Connecticut
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      Schizophrenia is one of the most heritable psychiatric disorders, and haplotype screens of affected families have uncovered several genes linked to this disorder, including the gene encoding neuregulin-1 (NRG1) (
      • Harrison P.J.
      • Weinberger D.R.
      Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence.
      ). NRG1 and the receptor tyrosine kinase, ErbB4, through which it exerts is actions, are critical for nervous system development. ErbB4 initiates downstream signaling events that control neuronal progenitor proliferation, interneuron migration from the ganglionic eminences, radial migration of glutamatergic neurons, oligodendrocyte development, and myelination as well as synaptic plasticity in the adult (
      • Mei L.
      • Xiong W.C.
      Neuregulin 1 in neural development, synaptic plasticity and schizophrenia.
      ). Interestingly, many of these same processes are disrupted in schizophrenia.
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