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Authors JMdND and AK contributed equally to this work.
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- N-Acetylcysteine for the Treatment of Glutathione Deficiency and Oxidative Stress in SchizophreniaBiological PsychiatryVol. 71Issue 11
- PreviewDespite decades of intense research and development, current treatments for schizophrenia (SZ) have not only met with limited efficacy but are also often associated with serious side effects, justifying the heightened interest in the development of alternate therapies (1). With mounting experimental evidence implicating glutathione (GSH) deficiency and increased oxidative stress in the pathophysiology of most major psychiatric disorders (2), novel neuroprotective strategies that aim to limit oxidative stress-mediated cellular damage in such disorders, including SZ, are being increasingly scrutinized (2,3).
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