Hamilton et al. (
1
) reported some very interesting and important findings in their article “Default-Mode
and Task-Positive Network Activity in Major Depressive Disorder: Implications for
Adaptive and Maladaptive Rumination.” In the article, the authors explored dominance
of the default-mode network (DMN) over the task-positive network (TPN) and how that
dominance might be related to depression and rumination. Dominance of the DMN over
the TPN was defined for time points where the DMN blood oxygen level dependent signal
was greater than the TPN blood oxygen level dependent signal. This calculation was
performed across the whole brain where the DMN and the TPN were defined from seed-based
approaches of Fox et al. (
2
) during eyes-shut resting state scans. The authors found that subjective reflection
scores from the Rumination Response Scale (RRS) of Treynor et al. (
3
) correlated negatively with DMN dominance. That is, for participants with major depressive
disorder (MDD), the more they reflected, the less dominance there was of the DMN over
the TPN. By contrast, depression sub-scales of the RRS correlated positively with
DMN dominance for participants with MDD. The authors did not find reliable correlations
between DMN dominance and RRS measures for the healthy control (HC) group. Therefore,
DMN dominance might be a reliable measure of depression severity.To read this article in full you will need to make a payment
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References
- Default-mode and task-positive network activity in major depressive disorder: Implications for adaptive and maladaptive rumination.Biol Psychiatry. 2011; 70: 327-333
- The human brain is intrinsically organized into dynamic, anticorrelated functional networks.Proc Natl Acad Sci U S A. 2005; 102: 9673
- Rumination reconsidered: A psychometric analysis.Cogn Ther Res. 2003; 27: 247
- A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks.Proc Natl Acad Sci U S A. 2008; 105: 12569-12574
- How do you feel—now?.Nature Reviews Neuroscience. 2009; 10: 59-70
- Experience sampling during fMRI reveals default network and executive system contributions to mind wandering.Proc Natl Acad Sci U S A. 2009; 106: 8719-8724
- Wandering minds: The default network and stimulus-independent thought.Science. 2007; 315: 393
- Depression, rumination and the default network.Soc Cogn Affect Neurosci. 2010; ([published online ahead of print September 19])
- Resting-state functional connectivity in major depression: Abnormally increased contributions from subgenual cingulate cortex and thalamus.Biol Psychiatry. 2007; 62: 429
- Deep brain stimulation for treatment-resistant depression.Neuron. 2005; 45: 651
- Common blood flow changes across visual tasks.J Cogn Neurosci. 1997; 9: 624-647
- Common blood flow changes across visual tasks.J Cogn Neurosci. 1997; 9: 648-663
Article info
Publication history
Accepted:
June 7,
2011
Received:
June 6,
2011
Identification
Copyright
© 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
ScienceDirect
Access this article on ScienceDirectLinked Article
- Default-Mode and Task-Positive Network Activity in Major Depressive Disorder: Implications for Adaptive and Maladaptive RuminationBiological PsychiatryVol. 70Issue 4
- PreviewMajor depressive disorder (MDD) has been associated reliably with ruminative responding; this kind of responding is composed of both maladaptive and adaptive components. Levels of activity in the default-mode network (DMN) relative to the task-positive network (TPN), as well as activity in structures that influence DMN and TPN functioning, may represent important neural substrates of maladaptive and adaptive rumination in MDD.
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