Hamilton et al. (
1) reported some very interesting and important findings in their article “Default-Mode and Task-Positive Network Activity in Major Depressive Disorder: Implications for Adaptive and Maladaptive Rumination.” In the article, the authors explored dominance of the default-mode network (DMN) over the task-positive network (TPN) and how that dominance might be related to depression and rumination. Dominance of the DMN over the TPN was defined for time points where the DMN blood oxygen level dependent signal was greater than the TPN blood oxygen level dependent signal. This calculation was performed across the whole brain where the DMN and the TPN were defined from seed-based approaches of Fox et al. (
- Hamilton P.J.
- Furman D.J.
- Chang C.
- Thomason M.E.
- Dennis E.
- Gotlib I.H.
Default-mode and task-positive network activity in major depressive disorder: Implications for adaptive and maladaptive rumination.
Biol Psychiatry. 2011; 70: 327-333
2) during eyes-shut resting state scans. The authors found that subjective reflection scores from the Rumination Response Scale (RRS) of Treynor et al. (
- Fox M.D.
- Snyder A.Z.
- Vincent M.
- Corbetta J.L.
- Van Essen D.C.
- Raichle M.E.
The human brain is intrinsically organized into dynamic, anticorrelated functional networks.
Proc Natl Acad Sci U S A. 2005; 102: 9673
3) correlated negatively with DMN dominance. That is, for participants with major depressive disorder (MDD), the more they reflected, the less dominance there was of the DMN over the TPN. By contrast, depression sub-scales of the RRS correlated positively with DMN dominance for participants with MDD. The authors did not find reliable correlations between DMN dominance and RRS measures for the healthy control (HC) group. Therefore, DMN dominance might be a reliable measure of depression severity.
- Treynor W.
- Gonzalez R.
- Nolen-Hoeksema S.
Rumination reconsidered: A psychometric analysis.
Cogn Ther Res. 2003; 27: 247
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- Default-mode and task-positive network activity in major depressive disorder: Implications for adaptive and maladaptive rumination.Biol Psychiatry. 2011; 70: 327-333
- The human brain is intrinsically organized into dynamic, anticorrelated functional networks.Proc Natl Acad Sci U S A. 2005; 102: 9673
- Rumination reconsidered: A psychometric analysis.Cogn Ther Res. 2003; 27: 247
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Accepted: June 7, 2011
Received: June 6, 2011
© 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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- Default-Mode and Task-Positive Network Activity in Major Depressive Disorder: Implications for Adaptive and Maladaptive RuminationBiological PsychiatryVol. 70Issue 4
- PreviewMajor depressive disorder (MDD) has been associated reliably with ruminative responding; this kind of responding is composed of both maladaptive and adaptive components. Levels of activity in the default-mode network (DMN) relative to the task-positive network (TPN), as well as activity in structures that influence DMN and TPN functioning, may represent important neural substrates of maladaptive and adaptive rumination in MDD.