- Åberg K.
- van den Oord E.J.C.G.
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- Epstein–Barr virus transformed DNA as a source of false positive findings in methylation studies of psychiatric conditions.Biol Psychiatry. 2011; 70: e25-e26
- Methylation matters: Interaction between methylation density and serotonin transporter genotype predicts unresolved loss or trauma.Biol Psychiatry. 2010; 68: 405-407
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- EBV transformation and cell culturing destabilizes DNA methylation in human lymphoblastoid cell lines.Genomics. 2009; 95: 73-83
- Extreme clonality in lymphoblastoid cell lines with implications for allele specific expression analyses.PLoS ONE. 2008; 3: e2966
- Comprehensive methylome map of lineage commitment from haematopoietic progenitors.Nature. 2010; 467: 338-342
- Analysis of whole genome biomarker expression in blood and brain.Am J Med Genet B Neuropsychiatr Genet. 2010; 153B: 919-936
The authors report no biomedical financial interests or potential conflicts of interest. On behalf of Dr. Philibert, the University of Iowa has filed intellectual property claims with respect to the serotonin transport protein. Dr. Philibert is a potential royalty holder on that application.
Please also see associated correspondence, doi:10.1016/j.biopsych.2011.01.042.
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- Epstein–Barr Virus Transformed DNA as a Source of False Positive Findings in Methylation Studies of Psychiatric ConditionsBiological PsychiatryVol. 70Issue 5
- PreviewMethylation patterns are tissue-specific (1). Methylation studies are therefore ideally performed in the tissue that is directly related to the disease of interest. However, for psychiatric conditions, it is not feasible to obtain brain tissue from (living) patients. In these instances, whole blood might serve as a proxy. There is indeed ample evidence suggesting that methylation signatures might not be limited to the affected tissue and are detectible in peripheral biofluids. One example involves the loss of imprinting of insulin-like growth factor-2, one of the best-studied epimutations that is associated with increased risk of colorectal cancer (2).