Correspondence| Volume 70, ISSUE 1, e1-e2, July 01, 2011

Hippocampal Glutamate Levels and Striatal Dopamine D2/3 Receptor Occupancy in Subjects at Ultra High Risk of Psychosis

      With great interest we read the recent article, “Altered Relationship Between Hippocampal Glutamate Levels and Striatal Dopamine Function in Subjects at Ultra High Risk of Psychosis” (
      • Stone J.M.
      • Howes O.D.
      • Egerton A.
      • Kambeitz J.
      • Allen P.
      • Lythgoe D.J.
      • et al.
      Altered relationship between hippocampal glutamate levels and striatal dopamine function in subjects at ultra high risk of psychosis.
      ). This study reported a negative relation between left hippocampal glutamate levels and presynaptic fluorine-18-L-dihydroxyphenylalanine ([18F]DOPA) uptake in the left striatum of patients with an at-risk mental state (ARMS, also referred to as ultra high risk [UHR] for psychosis) but not in healthy controls. Additionally, the authors found evidence that this relationship may predict later transition to psychosis. These results are an important step in unraveling the etiology of psychosis and schizophrenia and may point to the possibility for a glutamatergic pharmacologic intervention to decrease the risk of transition to psychosis.
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