Background
Biochemical diagnostics of ethanol intake would improve alcohol abuse treatment and
have applications in clinical trial and public safety settings. Self-reporting of
alcohol use has clinical utility but lacks the desired reliability. Previously, proposed
single-analyte biochemical tests of alcohol intake suffer from low sensitivity and
specificity or examine only acute drinking and have therefore seen limited clinical
use.
Methods
To address this unmet need, plasma protein biomarker discovery and validation were
performed with an alcohol self-administering nonhuman primate model system to develop
a diagnostic that accurately classifies subjects into nondrinking, nonabusive drinking,
and abusive drinking categories.
Results
A 17-plasma protein panel was determined that correctly classifies abusive drinking
with 100% sensitivity and also differentiates any level of drinking from alcohol abstinence
with 88% accuracy.
Conclusions
The biomarker panel reflects changes in multiple organ systems and suggests robust
changes in the plasma proteome with drinking that might serve as a sensitive and specific
diagnostic test. The specific plasma proteins altered with alcohol self-administration
might represent indicators of alcohol-induced stress on a variety of organ systems.
Key Words
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Article info
Publication history
Published online: March 18, 2010
Accepted:
January 18,
2010
Received in revised form:
January 15,
2010
Received:
October 15,
2009
Footnotes
Authors KAG and KEV contributed equally to this work.
Identification
Copyright
© 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
